Mouse Insulin Like Growth Factor I Receptor (IGF-IR) Monoclonal Antibody | anti-IGF1R antibody
MAb to IGF-Ir
Specific for the human IGF-1 receptor, and recognizes the alpha subunit. Inhibits binding of IGF-1 and IGF-2; inhibits cell growth.
NCBI and Uniprot Product Information
NCBI Description
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq]
Uniprot Description
Function: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. Ref.19 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, Ref.22 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. Ref.7 Ref.10 Ref.11 Ref.12 Ref.19 Ref.22
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Ref.12
Cofactor: Manganese.
Enzyme regulation: Autophosphorylation activates the kinase activity. Ref.9
Subunit structure: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Forms a hybrid receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with GNB2L1/RACK1. Ref.10 Ref.13 Ref.16 Ref.17 Ref.20 Ref.21
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Ref.8 Ref.14 Ref.15
Post-translational modification: The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin-like growth factor I (IGF I). Ref.10 Ref.12 Ref.18 Ref.23 Ref.24 Ref.25 Ref.26Phosphorylation of Tyr-980 is required for IRS1- and SHC1-binding.
Involvement in disease: Defects in IGF1R are a cause of insulin-like growth factor 1 resistance (IGF1RES) [
MIM:270450]. It is a disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1. Ref.27 Ref.28
Sequence similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.Contains 3 fibronectin type-III domains.Contains 1 protein kinase domain.
Sequence caution: The sequence BAG11657.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on IGF1R
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Product Notes
The IGF1R igf1r (Catalog #AAA311301) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Insulin Like Growth Factor I Receptor (IGF-IR), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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