Mouse anti-Human Inositol Monophosphatase 1 Monoclonal Antibody | anti-IMPA1 antibody
Mouse Anti Human Inositol Monophosphatase 1
Gene Names
Impa1; AI325909; 2610002K09Rik; 2900059K10Rik
Reactivity
Human
Applications
ELISA, Western Blot, Flow Cytometry, Functional Assay, Immunocytochemistry, Immunofluorescence
Purity
Antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Synonyms
Inositol Monophosphatase 1; Monoclonal Antibody; Mouse Anti Human Inositol Monophosphatase 1; IMPA1 Antibody; Inositol monophosphatase 1; IMP 1; IMPase 1; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; IMPA1; IMPA; IMP; Mouse Anti Human; anti-IMPA1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1 heavy chain and k light chain.
Clone Number
PAT2G5AT
Purity/Purification
Antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Form/Format
Sterile filtered colorless solution.
1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.
1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.
Sequence Length
277
Applicable Applications for anti-IMPA1 antibody
ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)
Immunogen
Anti-human IMPA1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human IMPA1 protein 1-277amino acids purified from E Coli.
Preparation and Storage
12 months at -20 degree C. 1 month at 4 degree C.
For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
Related Product Information for anti-IMPA1 antibody
Inositol monophosphatase1 (IMPA1) is responsible for the provision of inositol essential for synthesis of phosphatidylinositol and polyphosphoinositides. IMPA1 has a central role in the phosphatidylinositol signaling pathway by catalyzing the hydrolysis of inositol monophosphates. IMPA1 has been recognized as the pharmacological target for lithium action in the brain. The IMPA1 enzyme has a magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and ensuing depletion of inositol for phosphatidylinositol synthesis may perhaps explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder.
Product Categories/Family for anti-IMPA1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
30,436 Da
NCBI Official Full Name
inositol monophosphatase 1 isoform 1
NCBI Official Synonym Full Names
inositol (myo)-1(or 4)-monophosphatase 1
NCBI Official Symbol
Impa1
NCBI Official Synonym Symbols
AI325909; 2610002K09Rik; 2900059K10Rik
NCBI Protein Information
inositol monophosphatase 1
UniProt Protein Name
Inositol monophosphatase 1
Protein Family
UniProt Gene Name
Impa1
UniProt Synonym Gene Names
IMP 1; IMPase 1
Uniprot Description
IMPA1: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol- phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Belongs to the inositol monophosphatase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.25; EC 3.1.3.94; Motility/polarity/chemotaxis; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 3|3 A1
Cellular Component: axon; cell soma; cytoplasm
Molecular Function: inositol-1(or 4)-monophosphatase activity; lithium ion binding; magnesium ion binding; manganese ion binding; protein homodimerization activity
Biological Process: inositol metabolic process; inositol phosphate dephosphorylation; phosphate metabolic process; phosphatidylinositol biosynthetic process; signal transduction
Research Articles on IMPA1
Similar Products
Product Notes
The IMPA1 impa1 (Catalog #AAA146660) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti Human Inositol Monophosphatase 1 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Inositol Monophosphatase 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF). Researchers should empirically determine the suitability of the IMPA1 impa1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Inositol Monophosphatase 1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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