Mouse anti-Human IMP3 Monoclonal Antibody | anti-IMP3 antibody

IMP3 Monoclonal Antibody

Cat. Num. AAA3014318

• Gene Names: IGF2BP3; KOC; CT98; IMP3; KOC1; IMP-3; VICKZ3
• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: IMP3; Monoclonal Antibody; IMP3 Monoclonal Antibody; Insulin-like growth factor 2 mRNA-binding protein 3; IGF2 mRNA-binding protein 3; IMP-3; IGF-II mRNA-binding protein 3; KH domain-containing protein overexpressed in cancer; hKOC; VICKZ family member 3; IGF2BP3; KOC1; VICKZ3; anti-IMP3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Specificity: This antibody detects endogenous levels of IMP3 and does not cross-react with related proteins
• Purity/Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 579

• Applicable Applications for anti-IMP3 antibody: Western Blot (WB)
• Application Notes: WB: 1:1000
• Immunogen: Recombinant full length Human IMP3.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot detection of IMP3 antibody in MCF7, SKVO3, NTERA2, Jurkat, Hela and K562 cell lysates using IMP3 antibody (1:1000 diluted).)

Related Product Information for anti-IMP3 antibody

Imp3, also known as BRMS2, C15orf12 or MRPS4, is a 184 amino acid protein that contains one S4 RNA-binding domain and is the mammalian homolog of the yeast Imp3 protein. Localized to the nucleus, Imp3 exists as a component of a heterotrimeric complex consisting of MPP10, Imp3 and Imp4 and, in this complex, plays a key role in early cleavage events during pre-18S ribosomal processing. The gene encoding Imp3 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.

NCBI and Uniprot Product Information

• NCBI GI #: 30795212
• NCBI GeneID: 10643
• NCBI Accession #: NP_006538.2
• NCBI GenBank Nucleotide #: NP_006538.2
• UniProt Accession #: O00425
• Molecular Weight: Predicted Band Size: 70KDa; Observed Band Size: 70KDa
• NCBI Official Full Name: insulin-like growth factor 2 mRNA-binding protein 3
• NCBI Official Synonym Full Names: insulin like growth factor 2 mRNA binding protein 3
• NCBI Official Symbol: IGF2BP3
• NCBI Official Synonym Symbols: KOC; CT98; IMP3; KOC1; IMP-3; VICKZ3
• NCBI Protein Information: insulin-like growth factor 2 mRNA-binding protein 3
• UniProt Protein Name: Insulin-like growth factor 2 mRNA-binding protein 3
• Protein Family: U3 small nucleolar ribonucleoprotein protein
• UniProt Gene Name: IGF2BP3
• UniProt Synonym Gene Names: IMP3; KOC1; VICKZ3; IGF2 mRNA-binding protein 3; IMP-3; hKOC
• UniProt Entry Name: IF2B3_HUMAN

NCBI Description

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

Uniprot Description

IGF2BP3: RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3'-UTR of CD44 mRNA. Belongs to the RRM IMP/VICKZ family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Spliceosome; Translation

Chromosomal Location of Human Ortholog: 7p11

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; mRNA 3'-UTR binding; RNA binding; nucleotide binding; translation regulator activity; mRNA 5'-UTR binding

Biological Process: anatomical structure morphogenesis; mRNA transport; translation; negative regulation of translation; gene expression; regulation of cytokine biosynthetic process