Mouse anti-Human IL-7 IL7 Monoclonal Antibody | anti-IL7 antibody

IL7 antibody

Cat. Num. AAA532389

• Gene Names: IL7; IL-7
• Reactivity: Human IL-7
• Applications: ELISA, Western Blot
• Synonyms: IL7; Monoclonal Antibody; IL7 antibody; Monoclonal IL7; Anti-IL7; pre-B cell factor; IL-7; Interleukin 7; LP-1; Lymphopoietin 1antibody; IL 7; anti-IL7 antibody

• Host: Mouse
• Reactivity: Human IL-7
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: M912274
• Specificity: Human IL-7
• Form/Format: Lyophilized from PBS.
• Sequence Length: 115

• Applicable Applications for anti-IL7 antibody: ELISA (EIA), Inhibition, Western Blot (WB)
• Application Notes: ELISA: 2-4 ug/ml
• Biological Significance: IL7 is a hematopoietic growth factor which affects primarily early B and T cells. Produced by thymic stromal cells, spleen cells and keratinocytes, IL7 can also co-stimulate the proliferation of mature T cells in combination with other factors such as ConA and IL2. Human and Mouse IL7 is cross-species reactive.
• Immunogen: IL7 antibody was raised in mouse using highly pure recombinant human IL-7 as the immunogen.
• Preparation and Storage: Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-IL7 antibody

Mouse monoclonal IL7 antibody

Product Categories/Family for anti-IL7 antibody

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 315467871
• NCBI GeneID: 3574
• NCBI Accession #: NP_001186817.1
• NCBI GenBank Nucleotide #: NM_001199888.1
• UniProt Accession #: Q5FBX5; P13232
• Molecular Weight: 15 kDa (predicted detection band MW)
• NCBI Official Full Name: interleukin-7 isoform 4
• NCBI Official Synonym Full Names: interleukin 7
• NCBI Official Symbol: IL7
• NCBI Official Synonym Symbols: IL-7
• NCBI Protein Information: interleukin-7
• UniProt Protein Name: IL7 nirs variant 1
• Protein Family: Interleukin
• UniProt Gene Name: IL7
• UniProt Entry Name: Q5FBX5_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]

Uniprot Description

IL7: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Apoptosis; Cell development/differentiation; Cell cycle regulation; Cytokine

Chromosomal Location of Human Ortholog: 8q12-q13

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-7 receptor binding; protein binding; growth factor activity; cytokine activity

Biological Process: positive regulation of organ growth; humoral immune response; T cell lineage commitment; organ morphogenesis; positive regulation of T cell differentiation; cell-cell signaling; regulation of gene expression; homeostasis of number of cells within a tissue; negative regulation of catalytic activity; positive regulation of cell proliferation; positive regulation of B cell proliferation; negative regulation of apoptosis; bone resorption