Rabbit anti-Mouse IL2RG Monoclonal Antibody | anti-IL2RG antibody

Recombinant Anti-IL2RG Antibody, Rabbit Monoclonal

Cat. Num. AAA8110948

• Reactivity: Mouse
• Applications: ELISA, ELISA
• Purity: Protein A
• Synonyms: IL2RG; Monoclonal Antibody; Recombinant Anti-IL2RG Antibody; Rabbit Monoclonal; CD132/IL2RG Antibody; Rabbit MAb; interleukin 2 receptor; gamma; Anti-CD132 Antibody; Anti-gamma(c) Antibody; Anti-gc Antibody; Anti-[g]c Antibody; anti-IL2RG antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 005
• Specificity: Mouse CD132/IL2RG.; No cross-reactivity in ELISA with Human IL2RG
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-IL2RG antibody: ELISA (EIA), ELISA (EIA) (Det)
• Application Notes: ELISA: 1:5000-1:10,000; ELISA (Det): 1:1000-1:10,000; ELISA (Det): This antibody will detect Mouse CD132/IL2RG in ELISA pair set.; In a sandwich ELISA, it can be used as detection antibody when paired with.
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant Mouse CD132/IL2RG protein
• Conjugation: Unconjugated
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD132/IL2RG (rM CD132/IL2RG).
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-IL2RG antibody

The common gamma chain (gammac) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (gammac) (or IL2RG), is a cytokine receptor subunit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15, and the interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (X-SCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor based on chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why a deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.

Product Categories/Family for anti-IL2RG antibody

Common G-Chain signaling pathway

References

Russell SM, et al. (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. 262 (5141): 1880-3.Miyazaki T, et al. (1994) Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science. 266 (5187): 1045-7.Takeshita T, et al. (1992) Cloning of the gamma chain of the human IL-2 receptor. Science. 257 (5068): 379-82.

NCBI and Uniprot Product Information

• NCBI GI #: 7305181
• NCBI GeneID: 16186
• NCBI Accession #: NP_038591.1
• NCBI GenBank Nucleotide #: NM_013563.3
• UniProt Accession #: P34902
• Molecular Weight: 42,241 Da
• NCBI Official Full Name: cytokine receptor common subunit gamma
• UniProt Protein Name: Cytokine receptor common subunit gamma
• Protein Family: Cytokine receptor
• UniProt Gene Name: Il2rg
• UniProt Synonym Gene Names: IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG
• UniProt Entry Name: IL2RG_MOUSE

NCBI Description

This gene encodes a transmembrane protein that is a common subunit of several interleukin receptor complexes. These receptors are comprised of alpha and beta subunits in addition to this gamma subunit. Signalling through this pathway in important in immune cell differentiation and function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

Uniprot Description

IL2RG: Common subunit for the receptors for a variety of interleukins. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell- negative (XSCID); also known as agammaglobulinemia Swiss type. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell- mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Defects in IL2RG are the cause of X-linked combined immunodeficiency (XCID). XCID is a less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID. Belongs to the type I cytokine receptor family. Type 5 subfamily.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: cell surface; membrane; integral to membrane; external side of plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-7 binding; interleukin-2 binding

Biological Process: positive regulation of T cell differentiation in the thymus; positive regulation of lymphocyte differentiation; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; regulation of gene expression; positive regulation of B cell differentiation