Flow Cytometry (FC/FACS)
(Flow cytometric analysis of Human IL18R1(CD218a) expression on human whole blood granulocytes. Cells were stained with APC-conjugated anti-Human IL18R1(CD218a). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable granulocytes.)
Mouse anti-Human IL18R1 Monoclonal Antibody | anti-IL18R1 antibody
Anti-IL18R1 Antibody (APC), Mouse Monoclonal
Gene Names
IL18R1; CD218a; IL18RA; IL1RRP; CDw218a; IL-1Rrp
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Purity
Protein A
Synonyms
IL18R1; Monoclonal Antibody; Anti-IL18R1 Antibody (APC); Mouse Monoclonal; IL18R1 Antibody (APC); Mouse MAb; interleukin 18 receptor 1; Anti-CD218a Antibody; Anti-CDw218a Antibody; Anti-IL-1Rrp Antibody; Anti-IL18RA Antibody; Anti-IL1RRP Antibody; anti-IL18R1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG2a
Clone Number
17
Specificity
Human IL18R1
Purity/Purification
Protein A
Form/Format
Liquid; Aqueous solution containing 0.5% BSA and 0.1% sodium azide
Concentration
10ul/Test, 0.1mg/ml (varies by lot)
Applicable Applications for anti-IL18R1 antibody
Flow Cytometry (FC/FACS/FCM)
Immunogen
Recombinant Human IL18R1 protein
Conjugation
APC
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL18R1 (rh IL18R1) and conjugated with APC under optimum conditions, the unreacted APC was removed.
Preparation and Storage
This antibody can be stored at 2-8 degree C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Flow Cytometry (FC/FACS)
(Flow cytometric analysis of Human IL18R1(CD218a) expression on human whole blood granulocytes. Cells were stained with APC-conjugated anti-Human IL18R1(CD218a). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable granulocytes.)
Flow Cytometry (FC/FACS)
(Flow cytometric analysis of Human IL18R1(CD218a) expression on human whole blood granulocytes. Cells were stained with APC-conjugated anti-Human IL18R1(CD218a). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable granulocytes.)
Related Product Information for anti-IL18R1 antibody
Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in the lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from the brain, skeletal muscle, pancreas, and kidney. A high level of expression is found in Hodgkin disease cell lines. This receptor is specifically bound to interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.
Product Categories/Family for anti-IL18R1 antibody
References
Nadif R, et al.. (2006) IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. Eur Respir J. 28(6): 1100-5.Haralambieva IH, et al.. (2011) Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in hum oral immunity to smallpox vaccination in Caucasians and African Americans. J Infect Dis. 204(3): 433-41.Hulin-Curtis SL, et al.. (2012) Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis. Int J Immunogenet. 39(2): 106-9.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
62,304 Da
NCBI Official Full Name
interleukin-18 receptor 1
NCBI Official Synonym Full Names
interleukin 18 receptor 1
NCBI Official Symbol
IL18R1
NCBI Official Synonym Symbols
CD218a; IL18RA; IL1RRP; CDw218a; IL-1Rrp
NCBI Protein Information
interleukin-18 receptor 1; IL-18R1; IL1R-rp; IL-18R-1; cytokine receptor; IL1 receptor-related protein; CD218 antigen-like family member A
UniProt Protein Name
Interleukin-18 receptor 1
Protein Family
UniProt Gene Name
IL18R1
UniProt Synonym Gene Names
IL1RRP; IL-18R-1; IL-18R1; IL-1Rrp; IL1R-rp
UniProt Entry Name
IL18R_HUMAN
NCBI Description
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. [provided by RefSeq, Jul 2008]
Uniprot Description
IL18R1: Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B. Belongs to the interleukin-1 receptor family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q12
Cellular Component: plasma membrane; integral to membrane
Molecular Function: protein binding; receptor activity; interleukin-1 receptor activity; interleukin-18 receptor activity
Biological Process: positive regulation of interferon-gamma production; T-helper 1 cell differentiation; natural killer cell activation; positive regulation of NF-kappaB import into nucleus; immune response; signal transduction
Research Articles on IL18R1
Similar Products
Product Notes
The IL18R1 il18r1 (Catalog #AAA8104882) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-IL18R1 Antibody (APC), Mouse Monoclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IL18R1 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS/FCM). Researchers should empirically determine the suitability of the IL18R1 il18r1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL18R1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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