Mouse anti-Human IL-15 IL15 Monoclonal Antibody | anti-IL15 antibody

IL15 antibody

Cat. Num. AAA532187

• Gene Names: IL15; IL-15
• Reactivity: Human IL-15
• Applications: ELISA, Western Blot
• Synonyms: IL15; Monoclonal Antibody; IL15 antibody; Monoclonal IL15; Anti-IL15; IL 15; IL-15; Interleukin 15; IL-T; anti-IL15 antibody

• Host: Mouse
• Reactivity: Human IL-15
• Clonality: Monoclonal
• Isotype: IgG1 kappa
• Clone Number: M912272
• Specificity: Human IL-15
• Form/Format: Lyophilized from PBS.
• Sequence Length: 135

• Applicable Applications for anti-IL15 antibody: ELISA (EIA), Inhibition, Western Blot (WB)
• Application Notes: ELISA: 4-8 ug/ml; WB: 0.5-1 ug/ml
• Biological Significance: IL15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL2. IL15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL15 has been implicated with rheumatoid arthritis, inflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells.
• Immunogen: IL15 antibody was raised in mouse using using highly pure recombinant human IL-15 as the immunogen.
• Preparation and Storage: Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-IL15 antibody

Mouse monoclonal IL15 antibody

Product Categories/Family for anti-IL15 antibody

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 26787984
• NCBI GeneID: 3600
• NCBI Accession #: NP_751914.1
• NCBI GenBank Nucleotide #: NM_172174.2
• UniProt Accession #: P40933; O00440; O43512; Q495Z8; Q6FGX7; Q93058; Q9UBA3; D3DNZ2
• Molecular Weight: 13.5 kDa (predicted detection band MW)
• NCBI Official Synonym Full Names: interleukin 15
• NCBI Official Symbol: IL15
• NCBI Official Synonym Symbols: IL-15
• NCBI Protein Information: interleukin-15
• UniProt Protein Name: Interleukin-15
• Protein Family: Interleukin
• UniProt Gene Name: IL15
• UniProt Synonym Gene Names: IL-15
• UniProt Entry Name: IL15_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]

Uniprot Description

IL15: Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Cytokine; Cell cycle regulation; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q31

Cellular Component: nucleoplasm; Golgi apparatus; extracellular space; cell surface; membrane; integral to plasma membrane; cytoplasm; extracellular region; endosome

Molecular Function: protein binding; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine activity

Biological Process: positive regulation of interleukin-17 production; positive regulation of natural killer cell proliferation; positive regulation of immune response; NK T cell proliferation; negative regulation of smooth muscle cell proliferation; cell maturation; signal transduction; lymph node development; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of natural killer cell differentiation; extrathymic T cell selection; positive regulation of tissue remodeling; skeletal muscle atrophy; cell-cell signaling; natural killer cell differentiation; positive regulation of cell proliferation; regulation of T cell differentiation; immune response; positive regulation of T cell proliferation; regulation of defense response to virus by host; inflammatory response; hyaluronan metabolic process; aging; positive regulation of inflammatory response