Testing Data
(Cell Proliferation Induced by IL4 was Neutralized by Human IL4R Antibody. Recombinant Human IL4 stimulates proliferation in the TF-1 human erythroleukemia cell line. Proliferation elicited by Recombinant Human IL4 (0.2 ng/mL) is neutralized by increasing concentrations of Human IL4R Monoclonal Antibody. The IC50 is typically 1-4 ng/mL.)
Rabbit anti-Human IL-4R/CD124 Monoclonal Antibody | anti-IL4R antibody
IL-4R/CD124 Neutralizing Antibody
No cross-reactivity in ELISA with Mouse IL4R, Rat IL4R
Neutralization: The neutralization activity of IL4R Neutralizing Antibody is Measured by its ability to neutralize IL4 induced proliferation in the human erythroleukemia cell line (TF-1). The Neutralization titer (IC50) is typically 1-4ng/mL in the presence of 0.2ng/mL Recombinant Human IL4.
Testing Data
(Cell Proliferation Induced by IL4 was Neutralized by Human IL4R Antibody. Recombinant Human IL4 stimulates proliferation in the TF-1 human erythroleukemia cell line. Proliferation elicited by Recombinant Human IL4 (0.2 ng/mL) is neutralized by increasing concentrations of Human IL4R Monoclonal Antibody. The IC50 is typically 1-4 ng/mL.)
Testing Data
(Cell Proliferation Induced by IL4 was Neutralized by Human IL4R Antibody. Recombinant Human IL4 stimulates proliferation in the TF-1 human erythroleukemia cell line. Proliferation elicited by Recombinant Human IL4 (0.2 ng/mL) is neutralized by increasing concentrations of Human IL4R Monoclonal Antibody. The IC50 is typically 1-4 ng/mL.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Uniprot Description
IL4R: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Belongs to the type I cytokine receptor family. Type 4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 16p12.1-p11.2
Cellular Component: extracellular space; integral to plasma membrane; receptor complex
Molecular Function: protein binding; interleukin-4 receptor activity; receptor signaling protein activity
Biological Process: ovulation; positive regulation of T-helper 2 cell differentiation; negative regulation of T-helper 1 cell differentiation; response to estrogen stimulus; production of molecular mediator of acute inflammatory response; immune response; defense response to protozoan; signal transduction; regulation of cell proliferation; positive regulation of macrophage activation
Disease: Ige Responsiveness, Atopic; Human Immunodeficiency Virus Type 1, Susceptibility To
Research Articles on IL4R
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Product Notes
The IL4R il4r (Catalog #AAA8102681) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IL-4R/CD124 Neutralizing Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IL-4R/CD124 can be used in a range of immunoassay formats including, but not limited to, Blocking (BL), Neutralization. Block: In a functional ELISA, 1.2ug/mL of the Rabbit Anti-Human IL4R Monoclonal antibody will block 50% of the binding of 2ug/mL of Human IL4 to immobilized Recombinant Human IL4R ) coated at 0.5ug/mL (100uL/well). At 5ug/mL, this antibody will block >90% of the binding. Neutralization: The neutralization activity of IL4R Neutralizing Antibody is Measured by its ability to neutralize IL4 induced proliferation in the human erythroleukemia cell line (TF-1). The Neutralization titer (IC50) is typically 1-4ng/mL in the presence of 0.2ng/mL Recombinant Human IL4. Researchers should empirically determine the suitability of the IL4R il4r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-4R/CD124, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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