Mouse anti-Human IL-29 Monoclonal Antibody | anti-IFNL1 antibody

Anti-IL-29 Antibody, Mouse Monoclonal

Cat. Num. AAA8106377

• Gene Names: IFNL1; IL29; IL-29
• Reactivity: Human
• Applications: ELISA
• Purity: Protein A
• Synonyms: IL-29; Monoclonal Antibody; Anti-IL-29 Antibody; Mouse Monoclonal; IL-29 Antibody; Mouse MAb; interferon; lambda 1; Anti-IFNL1 Antibody; Anti-IL29 Antibody; anti-IFNL1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Clone Number: 09
• Specificity: Human IL-29
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-IFNL1 antibody: ELISA (EIA) (Cap)
• Application Notes: ELISA (Cap): This antibody will detect Human IL-29 in ELISA pair set.; In a sandwich ELISA, it can be used as capture antibody when paired with.
• Immunogen: Recombinant Human IL-29 Protein
• Conjugation: Unconjugated
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-29 (rh IL-29). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-IFNL1 antibody

Interleukin-29 (IL-29), also known as cytokine Zcyto21, Interferon lambda-1, IFN-lambda-1, and IFNL1, is a secreted protein that belongs to the IL-28/IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by a viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

References

Li MC, et al. (2006) Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells. Acta Pharmacol Sin. 27(4): 453-9.Wang J, et al. (2009) Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection. J Immunol. 182(3): 1296-304.Jordan WJ, et al. (2007) Modulation of the human cytokine response by interferon lambda-1 (IFN-lambda1/IL-29). Genes Immun. 8(1): 13-20.

NCBI and Uniprot Product Information

• NCBI GI #: 26024325
• NCBI GeneID: 282618
• NCBI Accession #: NP_742152.1
• NCBI GenBank Nucleotide #: NM_172140.1
• UniProt Accession #: Q8IU54; Q17R34; A0AV25
• Molecular Weight: 21,898 Da
• NCBI Official Full Name: interferon lambda-1
• NCBI Official Synonym Full Names: interferon, lambda 1
• NCBI Official Symbol: IFNL1
• NCBI Official Synonym Symbols: IL29; IL-29
• NCBI Protein Information: interferon lambda-1; IFN-lambda-1; interleukin-29; cytokine Zcyto21; interferon-lambda-1; interleukin 29 (interferon, lambda 1)
• UniProt Protein Name: Interferon lambda-1
• Protein Family: Interferon
• UniProt Gene Name: IFNL1
• UniProt Synonym Gene Names: IL29; ZCYTO21; IFN-lambda-1; IL-29
• UniProt Entry Name: IFNL1_HUMAN

NCBI Description

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

Uniprot Description

IL29: Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family.

Protein type: Cytokine; Secreted, signal peptide; Secreted; Cell cycle regulation

Chromosomal Location of Human Ortholog: 19q13.13

Cellular Component: extracellular space; extracellular region; interleukin-28 receptor complex

Molecular Function: cytokine activity; interleukin-28 receptor binding; receptor binding

Biological Process: positive regulation of immune response; positive regulation of transcription, DNA-dependent; positive regulation of JAK-STAT cascade; JAK-STAT cascade; negative regulation of T cell differentiation; negative regulation of cell proliferation; positive regulation of interferon-gamma production; negative regulation of interleukin-13 production; positive regulation of tyrosine phosphorylation of STAT protein; negative regulation of T-helper 2 type immune response; negative regulation of interleukin-5 production; positive regulation of MHC class I biosynthetic process; negative regulation of transcription, DNA-dependent; negative regulation of memory T cell differentiation; defense response to virus