Mouse anti-Human IL-25 Monoclonal Antibody | anti-IL25 antibody
Mouse Anti-Human IL-25-UNLB
Gene Names
IL25; IL17E
Reactivity
Human
Applications
ELISA
Synonyms
IL-25; Monoclonal Antibody; Mouse Anti-Human IL-25-UNLB; Mouse anti-Human Interleukin-25 (IL-25); anti-IL25 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
SB129e1
Specificity
Reacts with native and recombinant human IL-251
Interleukin-25 (IL-25), also known as IL-17E, is a 17kD protein and a recently identified member of the IL-17 cytokine family. This cytokine is secreted by a variety of cells, including type 2 helper T cells (Th2), bone marrow-derived mast cells and alveolar macrophages2. On target cells, IL-25 can induce the production of several type 2 cytokines including IL-4, IL-5 and IL-13 and implicates a role for this cytokine in type 2 immune response3. Studies have linked this cytokine to promoting airway hyperreactivity, limiting pro inflammatory cytokine production and chronic intestinal inflammation and providing protective immunity following intestinal helminth infection4-6.
Interleukin-25 (IL-25), also known as IL-17E, is a 17kD protein and a recently identified member of the IL-17 cytokine family. This cytokine is secreted by a variety of cells, including type 2 helper T cells (Th2), bone marrow-derived mast cells and alveolar macrophages2. On target cells, IL-25 can induce the production of several type 2 cytokines including IL-4, IL-5 and IL-13 and implicates a role for this cytokine in type 2 immune response3. Studies have linked this cytokine to promoting airway hyperreactivity, limiting pro inflammatory cytokine production and chronic intestinal inflammation and providing protective immunity following intestinal helminth infection4-6.
Form/Format
Purified (UNLB) Antibody
Applicable Applications for anti-IL25 antibody
ELISA
Application Notes
ELISA: 0.1 - 1.0ug/mL
Immunogen
Recombinant Human IL-25
Characterization
To ensure acceptable performance, each batch of product is tested by ELISA to conform to characteristics of a standard reference reagent.
Preparation and Storage
The purified (UNLB) antibody is supplied as 0.5mg purified immunoglobulin in 1.0mL of 100mM borate buffered saline, pH 8.2; store at 2-8 degree C.
Reagents are stable for the period shown on the label if stored as directed.
Reagents are stable for the period shown on the label if stored as directed.
References
1) Kleinschek, M.A. et al. (2007). J. Exp. Med. 204:161-70.
3) Fort, M.M. et al. (2001). Immunity. 15:985-95.
4) Owyang, A.M. et al. (2006). J. Exp. Med. 203:1105-16.
5) Stock, P. et al. (2009). J. Immunol. 182:5116-22.
6) Perrigoue, J.G. et al. (2008). Cell Microbiol. 10:1757-64.
3) Fort, M.M. et al. (2001). Immunity. 15:985-95.
4) Owyang, A.M. et al. (2006). J. Exp. Med. 203:1105-16.
5) Stock, P. et al. (2009). J. Immunol. 182:5116-22.
6) Perrigoue, J.G. et al. (2008). Cell Microbiol. 10:1757-64.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
20,330 Da
NCBI Official Full Name
interleukin-25 isoform 2
NCBI Official Synonym Full Names
interleukin 25
NCBI Official Symbol
IL25
NCBI Official Synonym Symbols
IL17E
NCBI Protein Information
interleukin-25; interleukin-17E
UniProt Protein Name
Interleukin-25
Protein Family
UniProt Gene Name
IL25
UniProt Synonym Gene Names
IL17E; IL-25; IL-17E
UniProt Entry Name
IL25_HUMAN
NCBI Description
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Uniprot Description
Function: Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.
Subcellular location: Secreted.
Tissue specificity: Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.
Sequence similarities: Belongs to the IL-17 family.
Research Articles on IL25
Similar Products
Product Notes
The IL25 il25 (Catalog #AAA670216) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human IL-25-UNLB reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IL-25 can be used in a range of immunoassay formats including, but not limited to, ELISA. ELISA: 0.1 - 1.0ug/mL. Researchers should empirically determine the suitability of the IL25 il25 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-25, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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