Mouse anti-Human IL-13 Monoclonal Antibody | anti-IL13 antibody

Anti-IL-13 Antibody, Mouse Monoclonal

Cat. Num. AAA8102507

• Gene Names: IL13; P600; IL-13
• Reactivity: Human
• Applications: ELISA
• Purity: Protein A
• Synonyms: IL-13; Monoclonal Antibody; Anti-IL-13 Antibody; Mouse Monoclonal; IL13/IL-13/ALRH Antibody; Mouse MAb; interleukin 13; Anti-ALRH Antibody; Anti-P600 Antibody; anti-IL13 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Clone Number: 02
• Specificity: Human IL13/IL-13/ALRH
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-IL13 antibody: ELISA (EIA) (Det)
• Application Notes: ELISA (Det): This antibody will detect Human IL13/IL-13/ALRH in ELISA pair set.; In a sandwich ELISA, it can be used as detection antibody when paired with.
• Immunogen: Recombinant Human IL13/IL-13/ALRH Protein
• Conjugation: Unconjugated
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL13/IL-13/ALRH (rh IL13/IL-13/ALRH). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-IL13 antibody

Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Ralpha) and at least one of two known IL-13-specific binding chains (IL-13 Ralpha1 and IL-13 Ralpha2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses, and diseases. Also, it inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. IL-13 protein and antibody are more importantly implicated as a central mediator of immunoregulatory processes in various cell types.

Product Categories/Family for anti-IL13 antibody

Cancer Drug Targets

References

Junttila IS, et al. (2008) Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med. 205(11): 2595-608.
Shimamura T, et al. (2008) Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model. J Immunol. 181(7): 4656-65.

NCBI and Uniprot Product Information

• NCBI GI #: 14091716
• NCBI GeneID: 3596
• Molecular Weight: Molecular Mass: 39 kDa; Actual Protein Molecular Mass: 50-55 kDa
• NCBI Official Full Name: interleukin 13
• NCBI Official Synonym Full Names: interleukin 13
• NCBI Official Symbol: IL13
• NCBI Official Synonym Symbols: P600; IL-13
• NCBI Protein Information: interleukin-13
• Protein Family: Interleukin

NCBI Description

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]