Western Blot (WB)
(Western blot analysis using IKBKB mouse mAb against truncated IKBKB recombinant protein (1).)
Mouse anti-Human IKBKB Monoclonal Antibody | anti-IKBKB antibody
Anti-IKBKB Mouse mAb
Western Blot (WB)
(Western blot analysis using IKBKB mouse mAb against truncated IKBKB recombinant protein (1).)
Western Blot (WB)
(Western blot analysis using IKBKB mouse mAb against truncated IKBKB recombinant protein (1).)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human colon carcinoma (A), breast carcinoma (B), kidney cell carcinoma (C), bladder carcinoma tumor (D), showing membrane and cytoplasmic localization using IKBKB mouse mAb with DAB staining.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human colon carcinoma (A), breast carcinoma (B), kidney cell carcinoma (C), bladder carcinoma tumor (D), showing membrane and cytoplasmic localization using IKBKB mouse mAb with DAB staining.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Description
IKKB: a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer.
Protein type: EC 2.7.11.10; IKK family; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 8p11.21
Cellular Component: cytoplasm; cytosol; IkappaB kinase complex; internal side of plasma membrane
Molecular Function: IkappaB kinase activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity
Biological Process: activation of NF-kappaB transcription factor; anatomical structure morphogenesis; cortical actin cytoskeleton organization and biogenesis; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; negative regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of phosphorylation; response to virus; serine phosphorylation of STAT protein; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway
Disease: Immunodeficiency 15
Research Articles on IKBKB
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Product Notes
The IKBKB ikbkb (Catalog #AAA475725) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-IKBKB Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IKBKB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the IKBKB ikbkb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IKBKB, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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