Testing Data
(1:1000 dilution of this antibody detected NFKBIA on 40ug of cell lysates)
Mouse IkB-alpha Monoclonal Antibody | anti-IkB-alpha antibody
IkB-alpha(N-term) Monoclonal Antibody
Testing Data
(1:1000 dilution of this antibody detected NFKBIA on 40ug of cell lysates)
Testing Data
(1:1000 dilution of this antibody detected NFKBIA on 40ug of cell lysates)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
Uniprot Description
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Research Articles on IkB-alpha
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Product Notes
The IkB-alpha nfkbia (Catalog #AAA9400313) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The IkB-alpha(N-term) Monoclonal Antibody reacts with Human, Porcine, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's IkB-alpha can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:1000. Researchers should empirically determine the suitability of the IkB-alpha nfkbia for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IkB-alpha, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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