Mouse IkappaB beta Monoclonal Antibody | anti-IkappaB beta antibody

IkappaB beta Monoclonal Antibody

Cat. Num. AAA2548948

• Gene Names: NFKBIB; IKBB; TRIP9
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Protein A Purification
• Synonyms: IkappaB beta; Monoclonal Antibody; IkappaB beta Monoclonal Antibody; NFKBIB; IKBB; TRIP9; NF-kappa-B inhibitor beta; NF-kappa-BIB; I-kappa-B-beta; IkB-B; IkB-beta; IkappaBbeta; Thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP-9; anti-IkappaB beta antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG
• Purity/Purification: Protein A Purification
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 270

• Applicable Applications for anti-IkappaB beta antibody: Immunohistochemistry (IHC) Paraffin (IHC-p)
• Application Notes: IHC: 1:100-200
• Immunogen: Recombinant Protein
• Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4.
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.

Related Product Information for anti-IkappaB beta antibody

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

NCBI and Uniprot Product Information

• NCBI GI #: 340805857
• NCBI GeneID: 4793
• NCBI Accession #: NP_001230045.1
• NCBI GenBank Nucleotide #: NM_001243116.1
• UniProt Accession #: Q15653; Q96BJ7; A8K3F4
• Molecular Weight: 35,530 Da
• NCBI Official Full Name: NF-kappa-B inhibitor beta isoform 2
• NCBI Official Synonym Full Names: NFKB inhibitor beta
• NCBI Official Symbol: NFKBIB
• NCBI Official Synonym Symbols: IKBB; TRIP9
• NCBI Protein Information: NF-kappa-B inhibitor beta
• UniProt Protein Name: NF-kappa-B inhibitor beta
• UniProt Gene Name: NFKBIB
• UniProt Synonym Gene Names: IKBB; TRIP9; NF-kappa-BIB; IkB-B; IkB-beta; IkappaBbeta; TR-interacting protein 9; TRIP-9

NCBI Description

The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]

Uniprot Description

IkB-beta: a protein of the NF-kappa-B inhibitor family. Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA- dependent inactivation. Association with inhibitor kappa B- interacting Ras-like proteins 1 and 2 may also explain the slower degradation. Interacts with ligand-binding domain of thyroid hormone receptor-beta, inhibitor kappa B-interacting Ras-like protein 1, inhibitor kappa B-interacting protein Ras2, p65 (RELA) and c-Rel. Expressed in all tissues examined.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytosol; nucleus

Molecular Function: protein binding; signal transducer activity; transcription coactivator activity

Biological Process: positive regulation of NF-kappaB transcription factor activity; signal transduction; transcription, DNA-dependent