Rabbit anti-Human IGJ Monoclonal Antibody | anti-IGJ antibody
Rabbit anti Human IGJ Monoclonal Antibody
Gene Names
JCHAIN; IGJ; JCH; IGCJ
Reactivity
Human
Applications
ELISA
Synonyms
IGJ ; Monoclonal Antibody; Rabbit anti Human IGJ Monoclonal Antibody; anti-IGJ antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Sequence Length
159
Applicable Applications for anti-IGJ antibody
ELISA (EIA)
Application Notes
ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human IGJ. The detection limit for Human IGJ is approximately 0.0195 ng/well.
Immunogen
Recombinant Human IGJ protein
Buffer
0.2 mum filtered solution in PBS with 5% trehalose
Preparation and Storage
This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-IGJ antibody
Immunoglobulin J chain, also known as IGJ and IGCJ, is a secreted polypeptide which is the first immunoglobulin-related polypeptide expressed during the embryogenesis and differentiation of B cells in the fetal liver. The joining Immunoglobulin J chain is a small polypeptide, expressed by mucosal and glandular plasma cells, which regulates polymer formation of immunoglobulin (Ig)A and IgM. Immunoglobulin J chain/IGJ serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. Immunoglobulin J chain/IGJ also help to bind these immunoglobulins to secretory component. J-chain incorporation into polymeric IgA (pIgA, mainly dimers) and pentameric IgM endows these antibodies with several salient features. Immunoglobulin J chain/IGJ is involved in creating the binding site for pIgR/SC in the Ig polymers, not only by determining the polymeric quaternary structure but apparently also by interacting directly with the receptor protein. Both the immunoglobulin J chain/IGJ and the pIgR/SC are key proteins in secretory immunity.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18,099 Da
NCBI Official Full Name
immunoglobulin J chain
NCBI Official Synonym Full Names
joining chain of multimeric IgA and IgM
NCBI Official Symbol
JCHAIN
NCBI Official Synonym Symbols
IGJ; JCH; IGCJ
NCBI Protein Information
immunoglobulin J chain
UniProt Protein Name
Immunoglobulin J chain
UniProt Gene Name
JCHAIN
UniProt Entry Name
IGJ_HUMAN
Uniprot Description
IGJ: Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q21
Cellular Component: extracellular region; extracellular space
Molecular Function: IgA binding; peptidoglycan binding; phosphatidylcholine binding; protein homodimerization activity; single-stranded DNA binding
Biological Process: adaptive immune response; antibacterial humoral response; glomerular filtration; innate immune response; positive regulation of protein oligomerization; receptor-mediated endocytosis; retinal homeostasis
Research Articles on IGJ
Similar Products
Product Notes
The IGJ jchain (Catalog #AAA2544397) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti Human IGJ Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IGJ can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human IGJ. The detection limit for Human IGJ is approximately 0.0195 ng/well. Researchers should empirically determine the suitability of the IGJ jchain for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IGJ , Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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