Western Blot (WB)
(Western Blot analysis of IFT57 expression in transfected 293T cell line by IFT57 monoclonal antibody (M04), clone 3G4.Lane 1: IFT57 transfected lysate(27.069 KDa).Lane 2: Non-transfected lysate.)
Mouse IFT57 Monoclonal Antibody | anti-IFT57 antibody
IFT57 (Intraflagellar transport 57 Homolog (Chlamydomonas), ESRRBL1, FLJ10147, HIPPI, MHS4R2) (Biotin)
Western Blot (WB)
(Western Blot analysis of IFT57 expression in transfected 293T cell line by IFT57 monoclonal antibody (M04), clone 3G4.Lane 1: IFT57 transfected lysate(27.069 KDa).Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of IFT57 expression in transfected 293T cell line by IFT57 monoclonal antibody (M04), clone 3G4.Lane 1: IFT57 transfected lysate(27.069 KDa).Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
Uniprot Description
IFT57: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. Belongs to the IFT57 family.
Chromosomal Location of Human Ortholog: 3q13.13
Cellular Component: Golgi apparatus; centrosome; photoreceptor connecting cilium; cilium
Molecular Function: protein binding; DNA binding
Biological Process: regulation of apoptosis; caspase activation; smoothened signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptosis; organelle organization and biogenesis; neural tube closure; intraflagellar transport; cilium biogenesis; heart looping; negative regulation of epithelial cell proliferation
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Product Notes
The IFT57 ift57 (Catalog #AAA6170931) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's IFT57 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the IFT57 ift57 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IFT57, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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