Rabbit anti-Human IFNGR1  Monoclonal Antibody | anti-IFNGR1  antibody

Rabbit anti Human IFNGR1  Monoclonal Antibody

Cat. Num. AAA2543944

• Gene Names: IFNGR1; CD119; IFNGR; IMD27A; IMD27B
• Reactivity: Human
• Applications: Western Blot, ELISA
• Synonyms: IFNGR1 ; Monoclonal Antibody; Rabbit anti Human IFNGR1 Monoclonal Antibody; anti-IFNGR1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 489

• Applicable Applications for anti-IFNGR1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 20-50 mug/mL; ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human IFNGR1. The detection limit for Human IFNGR1 is 0.00245 ng/well.
• Immunogen: Recombinant Human CD119 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-IFNGR1  antibody

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD119 (cluster of differentiation 119), also known as IFNGR1 (interferon gamma receptor 1), is part of the heterodimeric gamma interferon receptor which consists of IFNGR1 (CD119) and IFNGR2. The IFNGR1 gene encodes the ligand-binding chain (alpha) of the interteron receptor while IFNGR gene encodes the non-ligand binding partner. The ability of the interferon-gamma was achieved through binding to the interferon receptor CD119. After binding, the products of activated T-lymphocytes interferon-gamma exerts antiviral activity, growth inhibitory effect, and several immune- regulatory activities on a variety of cell types.

NCBI and Uniprot Product Information

• NCBI GI #: 4557880
• NCBI GeneID: 3459
• NCBI GenBank Nucleotide #: NM_000416.2
• Molecular Weight: 21,542 Da
• NCBI Official Full Name: interferon gamma receptor 1
• NCBI Official Synonym Full Names: interferon gamma receptor 1
• NCBI Official Symbol: IFNGR1
• NCBI Official Synonym Symbols: CD119; IFNGR; IMD27A; IMD27B
• NCBI Protein Information: interferon gamma receptor 1
• UniProt Protein Name: Interferon gamma receptor 1
• UniProt Gene Name: IFNGR1
• UniProt Synonym Gene Names: IFN-gamma-R-alpha
• UniProt Entry Name: INGR1_HUMAN

NCBI Description

This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]

Uniprot Description

IFNGR1: Receptor for interferon gamma. Two receptors bind one interferon gamma dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type II cytokine receptor family.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: interferon-gamma receptor activity; interleukin-20 binding; protein binding

Biological Process: response to virus; signal transduction

Disease: Helicobacter Pylori Infection, Susceptibility To; Hepatitis B Virus, Susceptibility To; Immunodeficiency 27a; Immunodeficiency 27b; Mycobacterium Tuberculosis, Susceptibility To