Mouse HSP70 Interacting Protein Monoclonal Antibody | anti-ST13 antibody

Mouse Anti Human HSP70 Interacting Protein

Cat. Num. AAA140271

• Gene Names: ST13; HIP; HOP; P48; AAG2; SNC6; HSPABP; FAM10A1; FAM10A4; HSPABP1; PRO0786
• Applications: ELISA, Western Blot
• Purity: ST13 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Synonyms: HSP70 Interacting Protein; Monoclonal Antibody; Mouse Anti Human HSP70 Interacting Protein; ST13 Antibody; Mouse Anti Human; AAG2; SNC6; HSPABP; FAM10A1; FAM10A4; HSPABP1; ST-13; Hsc70-interacting protein; Suppression of tumorigenicity protein 13; Putative tumor suppressor ST13; Protein FAM10A1; Progesterone receptor-associated p48 protein; Renal carcinoma antigen NY-REN-33; ST13; HIP; HOP; P48; PRO0786; FLJ27260; MGC129952; anti-ST13 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1 heavy chain and kappa light chain
• Clone Number: PAT1F1AT
• Purity/Purification: ST13 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Form/Format: 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
• Sequence Length: 369

• Applicable Applications for anti-ST13 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: ST13 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000 ~ 3000. Recommended starting dilution is 1:1000.
• Immunogen: Anti-human ST13 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human ST13 amino acids 1-369 purified from E Coli.
• Preparation and Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.; 12 months at -20 degree C. 1 month at 4 degree C.

Related Product Information for anti-ST13 antibody

Introduction: ST13 is an adaptor protein (co-chaperone) that mediates the association of HSP70 & HSP90 and appears in early receptor complexes. ST13 plays a role in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of ST13 is downregulated in colorectal carcinoma tissue signifying that is candidate tumor suppressor gene. Through common binding to both Hsp70 and Hsp90, ST13 functions as an adaptor that can integrate Hsp70 and Hsp90 interactions. The expression of ST13 decreases in colorectal cancer tissue compared with that in adjacent normal tissue. ST13 is mostly expressed in colorectal epithelia and adenocarcinoma cells. ST13 functions to promote the efficiency of glucocorticoid receptor maturation in cells. The expression levels of the ST13 gene were significantly decreased in primary tumors compared with adjacent mucosa.

Product Categories/Family for anti-ST13 antibody

Monoclonal Antibodies; Anti-Human Heat Shock Proteins; Monoclonal Antibodies; Anti Human Heat Shock Protein

NCBI and Uniprot Product Information

• NCBI GI #: 19923193
• NCBI GeneID: 6767
• NCBI Accession #: NP_003923.2
• NCBI GenBank Nucleotide #: NM_003932.4
• Molecular Weight: 41,332 Da
• NCBI Official Full Name: hsc70-interacting protein isoform 1
• NCBI Official Synonym Full Names: suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
• NCBI Official Symbol: ST13
• NCBI Official Synonym Symbols: HIP; HOP; P48; AAG2; SNC6; HSPABP; FAM10A1; FAM10A4; HSPABP1; PRO0786
• NCBI Protein Information: hsc70-interacting protein; Hsp70-interacting protein; aging-associated protein 2; heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; renal carcinoma antigen NY-REN-33; suppression of tumorigenicity 13 protein
• UniProt Protein Name: Hsc70-interacting protein
• Protein Family: Hsc70-interacting protein
• UniProt Gene Name: ST13
• UniProt Synonym Gene Names: AAG2; FAM10A1; HIP; SNC6; Hip
• UniProt Entry Name: F10A1_HUMAN

NCBI Description

The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Uniprot Description

HIP: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins. Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90. Interacts (via the C-terminus 303- 319 AA) with GRK5. Belongs to the FAM10 family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: protein complex; cytoplasm; cytosol

Molecular Function: protein binding, bridging; identical protein binding; protein domain specific binding; protein binding; chaperone binding; unfolded protein binding; dATP binding; protein complex binding; Hsp70 protein binding

Biological Process: protein folding; protein homooligomerization