Mouse anti-Cow High mobility group protein B1 Monoclonal Antibody | anti-HMGB1 antibody

High mobility group protein B1 Mouse mAb for Cow

Cat. Num. AAA435461

• Reactivity: Cow
• Applications: Western Blot
• Synonyms: High mobility group protein B1; Monoclonal Antibody; High mobility group protein B1 Mouse mAb for Cow; Amphoterin; Heparin-binding protein p30; high mobility group 1; High mobility group protein 1; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group box 1; HMG-1; HMG1; HMG3; SBP-1; Sulfoglucuronyl carbohydrate binding protein; anti-HMGB1 antibody

• Host: Mouse
• Reactivity: Cow
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 215

• Applicable Applications for anti-HMGB1 antibody: Western Blot (WB)
• Application Notes: WB: 1:1000-1:5000
• Source Note: This monoclonal antibody is produced by immunizing mice with a polypeptide corresponding to high mobility group protein B1 protein.
• Preparation and Storage: Store at -20 degree C. Stable for one year from the date of shipment.

Western Blot (WB)

Related Product Information for anti-HMGB1 antibody

High mobility group protein B1 encoded by the gene HMGB1 belongs to high mobility group and contains HMG-box domain. Like the histones, the protein is among the most important chromatin proteins. In the nucleus it interacts with nucleosomes, transcription factors, and histones. This nuclear protein organizes the DNA and regulates transcription. After binding, the protein bends DNA, which facilitates the binding of other proteins. The protein has been shown to play an important role in helping the RAG endonuclease form a paired complex during V(D)J recombination.

Product Categories/Family for anti-HMGB1 antibody

Livestock

NCBI and Uniprot Product Information

• NCBI GI #: 41386729
• NCBI GeneID: 282691
• NCBI Accession #: NP_788785
• NCBI GenBank Nucleotide #: NM_176612.1
• UniProt Accession #: P10103; Q3ZC39; A5D9G8
• Molecular Weight: Predicted MW: 25
• NCBI Official Full Name: high mobility group protein B1
• NCBI Official Synonym Full Names: high mobility group box 1
• NCBI Official Symbol: HMGB1
• NCBI Protein Information: high mobility group protein B1
• UniProt Protein Name: High mobility group protein B1
• Protein Family: High mobility group protein
• UniProt Gene Name: HMGB1
• UniProt Synonym Gene Names: HMG1; HMG-1

Uniprot Description

Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins ().