Testing Data
(Image: HeLa cells grown in tissue culture and stained with HMGB1 (red), Neuromics' chicken polyclonal antibody to Vimentin (Cat#CH22108) (green) and DNA (blue). The HMGB1 antibody reveals strong nuclear staining which overlaps with the DNA stain. Protocol on Datasheet.)
High-mobility group Protein B1 Antibody | anti-B1/HMGP1 antibody
High-mobility group Protein B1, Monoclonal Antibody, Mouse
Testing Data
(Image: HeLa cells grown in tissue culture and stained with HMGB1 (red), Neuromics' chicken polyclonal antibody to Vimentin (Cat#CH22108) (green) and DNA (blue). The HMGB1 antibody reveals strong nuclear staining which overlaps with the DNA stain. Protocol on Datasheet.)
Testing Data
(Image: HeLa cells grown in tissue culture and stained with HMGB1 (red), Neuromics' chicken polyclonal antibody to Vimentin (Cat#CH22108) (green) and DNA (blue). The HMGB1 antibody reveals strong nuclear staining which overlaps with the DNA stain. Protocol on Datasheet.)
Testing Data
(Image: Blot of crude HeLa cell extract. HMGB1 runs at an apparent molecular weight of 25kDa. Protocol on Datasheet.)
Testing Data
(Image: Blot of crude HeLa cell extract. HMGB1 runs at an apparent molecular weight of 25kDa. Protocol on Datasheet.)
NCBI and Uniprot Product Information
Uniprot Description
HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Belongs to the HMGB family.
Protein type: Nuclear receptor co-regulator; DNA repair, damage
Chromosomal Location of Human Ortholog: 13q12
Cellular Component: nucleoplasm; extracellular space; cell surface; transcriptional repressor complex; extracellular region; condensed chromosome; nucleus
Molecular Function: RAGE receptor binding; protein binding; double-stranded DNA binding; damaged DNA binding; cytokine activity; chromatin binding; transcription factor binding; DNA bending activity; transcription factor activity; single-stranded DNA binding; chemoattractant activity
Biological Process: negative regulation of transcriptional preinitiation complex assembly; V(D)J recombination; DNA topological change; positive regulation of apoptosis; apoptosis; positive regulation of caspase activity; base-excision repair, DNA ligation; negative regulation of transcription from RNA polymerase II promoter; DNA recombination; chromatin remodeling; regulation of transcription from RNA polymerase II promoter; myeloid dendritic cell activation; inflammatory response to antigenic stimulus; positive chemotaxis; dendritic cell chemotaxis; DNA ligation during DNA repair; innate immune response; positive regulation of transcription from RNA polymerase II promoter; DNA fragmentation during apoptosis; neurite development; cell structure disassembly during apoptosis; positive regulation of DNA binding
Research Articles on B1/HMGP1
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Product Notes
The B1/HMGP1 hmgb1 (Catalog #AAA555028) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The High-mobility group Protein B1, Monoclonal Antibody, Mouse reacts with Human, Mouse, Porcine, Multiple Mammalian and may cross-react with other species as described in the data sheet. AAA Biotech's High-mobility group Protein B1 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the B1/HMGP1 hmgb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "High-mobility group Protein B1, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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