Testing Data
Mouse anti-Human hBUBR1 Monoclonal Antibody | anti-hBUBR1 antibody
Anti-hBUBR1 Antibody
Reactivity
Human
Applications
Western Blot, Immunoprecipitation, Immunofluorescence
Purity
Purified ascites
Synonyms
hBUBR1; Monoclonal Antibody; Anti-hBUBR1 Antibody; anti-hBUBR1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
P10.8G1.G11.H12
Purity/Purification
Purified ascites
Form/Format
Liquid
Concentration
100ug/100ul (varies by lot)
Applicable Applications for anti-hBUBR1 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
Storage Buffer
PBS, pH 7.4 with 0.02% sodium azide.
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Testing Data
Testing Data
Related Product Information for anti-hBUBR1 antibody
The BUB family of serine/threonine kinases is a major target of oncology therapeutic research and development. hBUB1 and hBUBR1 are kinases that associate with hBUB3 and are essential components of the mitotic checkpoint. hBUBR1 appears to provide two checkpoint functions by monitoring CENP-E-dependent activities at the kinetochore and by regulating cyclosome/APC activity.hBUBR1 is required in order for microtubule inhibitors to arrest cells in mitosis. Non-mutational inactivation of hBUB1 and hBUBR1 appear related to stage of colon cancer and could be related to aneuploidy in human colorectal and other cancers.
References
Chan GK, Jablonski SA, et al. "Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC, " J Cell Biol Sept 1999;146 (5):941-54 [PMID: 10477750]
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Product Notes
The hBUBR1 (Catalog #AAA418470) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-hBUBR1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's hBUBR1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF). Researchers should empirically determine the suitability of the hBUBR1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "hBUBR1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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