Western Blot (WB)
(Western blot analysis using HAS1 mAb against human HAS1 (AA)
Mouse anti-Human HAS1 Monoclonal Antibody | anti-HAS1 antibody
Anti-HAS1 Mouse mAb
Western Blot (WB)
(Western blot analysis using HAS1 mAb against human HAS1 (AA)
Western Blot (WB)
(Western blot analysis using HAS1 mAb against human HAS1 (AA)
Immunofluorescence (IF)
(Immunofluorescence analysis of U251 cells using HAS1 mAb (green). Red)
Immunofluorescence (IF)
(Immunofluorescence analysis of U251 cells using HAS1 mAb (green). Red)
NCBI and Uniprot Product Information
NCBI Description
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Description
HAS1: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate. Belongs to the NodC/HAS family.
Protein type: Cell adhesion; EC 2.4.1.212; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transferase
Chromosomal Location of Human Ortholog: 19q13.41
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: hyaluronan synthase activity
Biological Process: cell adhesion; extracellular polysaccharide biosynthetic process; glycosaminoglycan biosynthetic process; hyaluronan biosynthetic process
Research Articles on HAS1
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Product Notes
The HAS1 has1 (Catalog #AAA476050) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-HAS1 Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HAS1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC). Researchers should empirically determine the suitability of the HAS1 has1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HAS1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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