Rabbit H Cadherin Monoclonal Antibody | anti-CDHH antibody

H Cadherin Antibody

Cat. Num. AAA9436596

• Gene Names: CDH13; CDHH; P105
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: ProA affinity purified
• Synonyms: H Cadherin; Monoclonal Antibody; H Cadherin Antibody; CAD13_HUMAN antibody; Cadherin-13 antibody; CDH13 antibody; CDHH antibody; H-cadherin antibody; Heart cadherin antibody; P105 antibody; T cad antibody; T Cadherin antibody; T-cad antibody; T-cadherin antibody; Truncated cadherin antibody; anti-CDHH antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Clone Number: JB14-48
• Purity/Purification: ProA affinity purified
• Form/Format: 1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Applicable Applications for anti-CDHH antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50-1:200
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant protein within human H Cadherin aa 1-200.
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C.

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded rat skeletal muscle tissue using anti-H Cadherin antibody. Counter stained with hematoxylin.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-H Cadherin antibody. Counter stained with hematoxylin.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human fetal skeletal muscle tissue using anti-H Cadherin antibody. Counter stained with hematoxylin.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti-H Cadherin antibody. Counter stained with hematoxylin.)

Related Product Information for anti-CDHH antibody

Cadherins comprise a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogen-esis. Cadherins each contain a large extracellular domains characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as beta-catenin, to regulate cadherin function. T-cadherin (for truncated-cadherin), also designated heart-cadherin or cadherin-13) expression levels have been shown to be reduced in human breast cancers and carcinoma cell lines. Evidence suggests that decreased levels of T-cadherin indicate a progression in breast malignancies.

Product Categories/Family for anti-CDHH antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 1705552
• NCBI GeneID: 1012
• UniProt Accession #: P55290; Q6GTW4; Q8TBX3; A8W476; A8W477; B7Z590; C9JRI6; J3KN62
• Molecular Weight: 713
• NCBI Official Full Name: Cadherin-13
• NCBI Official Synonym Full Names: cadherin 13
• NCBI Official Symbol: CDH13
• NCBI Official Synonym Symbols: CDHH; P105
• NCBI Protein Information: cadherin-13; T-cad; T-cadherin; heart cadherin; H-cadherin (heart); cadherin 13, H-cadherin (heart)
• UniProt Protein Name: Cadherin-13
• UniProt Gene Name: CDH13
• UniProt Synonym Gene Names: CDHH; H-cadherin; T-cad; T-cadherin
• UniProt Entry Name: CAD13_HUMAN

NCBI Description

This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]

Uniprot Description

CDH13: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; Cell adhesion

Chromosomal Location of Human Ortholog: 16q23.3

Cellular Component: extracellular space; neuron projection; focal adhesion; cytoplasm; plasma membrane; caveola; external side of plasma membrane

Molecular Function: adiponectin binding; protein homodimerization activity; cadherin binding; low-density lipoprotein binding; calcium ion binding

Biological Process: lamellipodium biogenesis; intercellular junction assembly and maintenance; positive regulation of positive chemotaxis; positive regulation of smooth muscle cell proliferation; Rac protein signal transduction; positive regulation of calcium-mediated signaling; negative regulation of cell adhesion; keratinocyte proliferation; Rho protein signal transduction; regulation of epidermal growth factor receptor signaling pathway; low density lipoprotein mediated signaling; negative regulation of cell proliferation; localization within membrane; calcium-dependent cell-cell adhesion; regulation of endocytosis; endothelial cell migration; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; sprouting angiogenesis; positive regulation of cell-matrix adhesion; homophilic cell adhesion; positive regulation of cell migration