Western Blot (WB)
(Western blot analysis using GPNMB mAb against human GPNMB recombinant protein. (Expected MW is 47.0 kDa))
Mouse anti-Human GPNMB Monoclonal Antibody | anti-GPNMB antibody
Anti-GPNMB Mouse mAb
Western Blot (WB)
(Western blot analysis using GPNMB mAb against human GPNMB recombinant protein. (Expected MW is 47.0 kDa))
Western Blot (WB)
(Western blot analysis using GPNMB mAb against human GPNMB recombinant protein. (Expected MW is 47.0 kDa))
Western Blot (WB)
(Western blot analysis using GPNMB mAb against HEK293 (1) and GPNMB (AA)
Western Blot (WB)
(Western blot analysis using GPNMB mAb against HEK293 (1) and GPNMB (AA)
Western Blot (WB)
(Western blot analysis using GPNMB mouse mAb against PANC1 (1) and PC-3 (2) cell lysate.)
Western Blot (WB)
(Western blot analysis using GPNMB mouse mAb against PANC1 (1) and PC-3 (2) cell lysate.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded breast cancer tissues using GPNMB mouse mAb with DAB staining.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded breast cancer tissues using GPNMB mouse mAb with DAB staining.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded esophagus cancer tissues using GPNMB mouse mAb with DAB staining.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded esophagus cancer tissues using GPNMB mouse mAb with DAB staining.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
GPNMB: Could be a melanogenic enzyme. Belongs to the PMEL/NMB family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 7p15.3
Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane
Molecular Function: heparin binding; integrin binding; protein binding; receptor agonist activity; syndecan binding
Biological Process: cell adhesion; cell-cell signaling; negative regulation of cell proliferation; negative regulation of cytokine production; negative regulation of T cell activation; negative regulation of T cell proliferation; positive regulation of cell migration; positive regulation of protein amino acid autophosphorylation; positive regulation of protein amino acid phosphorylation; regulation of tissue remodeling; signal transduction
Research Articles on GPNMB
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Product Notes
The GPNMB gpnmb (Catalog #AAA476431) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-GPNMB Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GPNMB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the GPNMB gpnmb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GPNMB, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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