Rabbit anti-Mouse GM-CSF Monoclonal Antibody | anti-CSF2 antibody

Recombinant Anti-GM-CSF Antibody, Rabbit Monoclonal

Cat. Num. AAA8112269

• Gene Names: Csf2; Csfgm; GMCSF; Gm-CSf; MGI-IGM
• Reactivity: Mouse
• Applications: ELISA, ELISA
• Purity: Protein A
• Synonyms: GM-CSF; Monoclonal Antibody; Recombinant Anti-GM-CSF Antibody; Rabbit Monoclonal; GM-CSF/CSF2 Antibody; Rabbit MAb; colony stimulating factor 2 (granulocyte-macrophage); Anti-Csfgm Antibody; Anti-Gm-CSf Antibody; Anti-GMCSF Antibody; Anti-MGI-IGM Antibody; anti-CSF2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 017
• Specificity: Mouse GM-CSF/CSF2
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-CSF2 antibody: ELISA (EIA), ELISA (EIA) (Cap)
• Application Notes: ELISA: 1:5000-1:10,000; ELISA (Cap): 1:250-1:2000; ELISA (Cap): This antibody will detect Mouse GM-CSF/CSF2 in ELISA pair set.; In a sandwich ELISA, it can be used as capture antibody.
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant Mouse GM-CSF/CSF2 Protein
• Conjugation: Unconjugated
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse GM-CSF/CSF2 (rM GM-CSF/CSF2).
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CSF2 antibody

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestational tissues synthesise GM-CSF under direction by ovarian steroid hormones and signalling agents originating in male seminal fluid and the conceptus. The pre-implantation embryo, invading placental trophoblast cells and the abundant populations of leukocytes controlling maternal immune tolerance are all subject to GM-CSF regulation. GM-CSF stimulates the differentiation of hematopoietic progenitors to monocytes and neutrophils, and reduces the risk for febrile neutropenia in cancer patients. GM-CSF also has been shown to induce the differentiation of myeloid dendritic cells (DCs) that promote the development of T-helper type 1 (cellular) immune responses in cognate T cells. The active form of the protein is found extracellularly as a homodimer, and the encoding gene is localized to a related gene cluster at chromosome region 5q31 which is known to be associated with 5q-syndrome and acute myelogenous leukemia. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has been utilized in the clinical management of multiple disease processes. Most recently, GM-CSF has been incorporated into the treatment of malignancies as a sole therapy, as well as a vaccine adjuvant. While the benefits of GM-CSF in this arena have been promising, recent reports have suggested the potential for GM-CSF to induce immune suppression and, thus, negatively impact outcomes in the management of cancer patients. GM-CSF deficiency in pregnancy adversely impacts fetal and placental development, as well as progeny viability and growth after birth, highlighting this cytokine as a central maternal determinant of pregnancy outcome with clinical relevance in human fertility.

Product Categories/Family for anti-CSF2 antibody

Cancer Drug Targets; IL17 signaling pathway

References

Robertson SA. (2007) GM-CSF regulation of embryo development and pregnancy. Cytokine Growth Factor Rev. 18(3-4): 287-98.
Waller EK. (2007) The role of sargramostim (rhGM-CSF) as immunotherapy. Oncologist. 12 Suppl 2: 22-6.
Clive KS, et al. (2010) Use of GM-CSF as an adjuvant with cancer vaccines: beneficial or detrimental? Expert Rev Vaccines. 9(5): 519-25.

NCBI and Uniprot Product Information

• NCBI GI #: 110625658
• NCBI GeneID: 12981
• NCBI Accession #: NP_034099.2
• NCBI GenBank Nucleotide #: NM_009969.4
• UniProt Accession #: P01587
• Molecular Weight: 16,091 Da
• NCBI Official Full Name: granulocyte-macrophage colony-stimulating factor
• NCBI Official Synonym Full Names: colony stimulating factor 2 (granulocyte-macrophage)
• NCBI Official Symbol: Csf2
• NCBI Official Synonym Symbols: Csfgm; GMCSF; Gm-CSf; MGI-IGM
• NCBI Protein Information: granulocyte-macrophage colony-stimulating factor; CSF; granulocyte-macrophage colony stimulating factor 2; put. GM-CSF
• UniProt Protein Name: Granulocyte-macrophage colony-stimulating factor
• Protein Family: Granulocyte-macrophage colony-stimulating factor
• UniProt Gene Name: Csf2
• UniProt Synonym Gene Names: Csfgm; GM-CSF; CSF
• UniProt Entry Name: CSF2_MOUSE

Uniprot Description

GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family.

Protein type: Secreted; Cytokine; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity

Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; macrophage activation; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of gene expression; positive regulation of interleukin-23 production; positive regulation of cell proliferation; myeloid dendritic cell differentiation; immune response; positive regulation of DNA replication; regulation of cell proliferation