Mouse GluR3 Monoclonal Antibody | anti-GRIA3 antibody

GluR3 (Glutamate Receptor)

Cat. Num. AAA604326

• Gene Names: GRIA3; GLUR3; GLURC; GluA3; MRX94; GLUR-C; GLUR-K3
• Reactivity: Human, Macaque, Rat
• Applications: Western Blot, Immunocytochemistry, Flow Cytometry, Functional Assay, Immunofluorescence
• Purity: Affinity Purified; Purified by Protein A chromatography.
• Synonyms: GluR3; Monoclonal Antibody; GluR3 (Glutamate Receptor); Anti -GluR3 (Glutamate Receptor); anti-GRIA3 antibody

• Host: Mouse
• Reactivity: Human, Macaque, Rat
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 6A90
• Specificity: Recognizes rat Glutamate Receptor 3 (GluR3) at ~98kD. Does not react with cells transfected with GluR1, GluR2 or GluR4. Species Crossreactivity: human, monkey. Reactivity has been confirmed with HEK293 cells transfected with AMPA GluR cDNAs as well as human, rat, and macaque monkey brain extracts by Western Blot and rat hippocampus by immunofluorescence, immunocytochemistry, and immunogold labeling/electron microscopy.
• Purity/Purification: Affinity Purified; Purified by Protein A chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

• Applicable Applications for anti-GRIA3 antibody: Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS), Immunofluorescence (IF)
• Application Notes: Suitable for use in Western Blot, Immunocytochemistry, Immunofluorescence and Electron Microscopy.
• Immunogen: Fusion protein encompassing the N-terminal region of rat GluR3.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-GRIA3 antibody

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. Regulation of fast excitatory synaptic neurotransmission is mediated primarily by ionotropic glutamate receptors (iGluR); ligand-gated cation (principally Ca2+) channels found on postsynaptic neurons throughout the central nervous system. Pharmacologic properties and amino acid sequence similarities allow classification of iGluR into three main subfamilies named for their principal agonists: 1) NMDA (N-methyl-D-aspartate) receptors, and the two non-NMDA receptor subfamilies,

Product Categories/Family for anti-GRIA3 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 163659858
• NCBI GeneID: 2892
• NCBI Accession #: NP_000819.3
• NCBI GenBank Nucleotide #: NM_000828.4
• UniProt Accession #: P42263; Q4VXD5; Q4VXD6; Q9HDA0; Q9HDA1; Q9HDA2; D3DTF1; Q17R51; Q4TT43; Q5XKG2; Q9P0H1; Q9P0H2; Q9UHA9
• Molecular Weight: 101,157 Da
• NCBI Official Full Name: glutamate receptor 3 isoform 2
• NCBI Official Synonym Full Names: glutamate receptor, ionotrophic, AMPA 3
• NCBI Official Symbol: GRIA3
• NCBI Official Synonym Symbols: GLUR3; GLURC; GluA3; MRX94; GLUR-C; GLUR-K3
• NCBI Protein Information: glutamate receptor 3; gluR-3; dJ1171F9.1; OTTHUMP00000024261; OTTHUMP00000024262; glutamate receptor C; glutamate receptor subunit 3; AMPA-selective glutamate receptor 3; glutamate receptor ionotropic, AMPA 3
• UniProt Protein Name: Glutamate receptor 3
• Protein Family: Glutamate receptor
• UniProt Gene Name: GRIA3
• UniProt Synonym Gene Names: GLUR3; GLURC
• UniProt Entry Name: GRIA3_HUMAN

NCBI Description

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq]

Uniprot Description

GluR3: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Interacts with protein kinase C-alpha binding protein. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated

Chromosomal Location of Human Ortholog: Xq25

Cellular Component: postsynaptic membrane; dendrite; plasma membrane; cell junction

Molecular Function: extracellular-glutamate-gated ion channel activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Biological Process: synaptic transmission, glutamatergic; synaptic transmission; transport; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway

Disease: Mental Retardation, X-linked, Syndromic, Wu Type