Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of NMDAR1 NMDA receptor protein using Mouse Anti-NMDAR1 NMDA receptor Monoclonal Antibody, Clone S308-48. Primary Antibody: Mouse Anti-NMDAR1 NMDA receptor Monoclonal Antibody at 1:1000.)
Mouse GluN1-NR1 Monoclonal Antibody | anti-Grin1 antibody
GluN1-NR1 Antibody: ATTO 488
Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of NMDAR1 NMDA receptor protein using Mouse Anti-NMDAR1 NMDA receptor Monoclonal Antibody, Clone S308-48. Primary Antibody: Mouse Anti-NMDAR1 NMDA receptor Monoclonal Antibody at 1:1000.)
Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of NMDAR1 NMDA receptor protein using Mouse Anti-NMDAR1 NMDA receptor Monoclonal Antibody, Clone S308-48. Primary Antibody: Mouse Anti-NMDAR1 NMDA receptor Monoclonal Antibody at 1:1000.)
Scientific Background: The NMDA receptor (NMDAR), a glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function (1). The NMDA receptor forms a heterotetramer between two NR1 and two NR2 subunits (the subunits are also called glutamate-binding NMDA receptor subunits or GluN for short); two obligatory NR1 subunits and two regionally localized NR2 subunits. A related gene family of NR3 A and B subunits have an inhibitory effect on receptor activity. Multiple receptor isoforms with distinct brain distributions and functional properties arise by selective splicing of the NR1 transcripts and differential expression of the NR2 subunits.
NCBI and Uniprot Product Information
NCBI Description
subunit of NMDA-preferring ionotropic glutamate receptors; may play a role in long term potentiation [RGD, Feb 2006]
Uniprot Description
NMDAR1: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Three alternatively-spliced isoforms have been described.
Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral; Channel, calcium
Cellular Component: cell surface; integral to plasma membrane; endoplasmic reticulum; cell; dendrite; postsynaptic density; dendritic spine; terminal button; excitatory synapse; N-methyl-D-aspartate selective glutamate receptor complex; postsynaptic membrane; synaptic vesicle; cell soma; membrane; cytoplasm; synapse; cell junction
Molecular Function: protein dimerization activity; voltage-gated cation channel activity; neurotransmitter binding; glutamate receptor binding; calcium channel activity; calcium ion binding; calmodulin binding; protein binding; enzyme binding; extracellular-glutamate-gated ion channel activity; glutamate binding; ionotropic glutamate receptor activity; protein heterodimerization activity; N-methyl-D-aspartate selective glutamate receptor activity; glycine binding; cation channel activity; receptor binding
Biological Process: regulation of long-term neuronal synaptic plasticity; startle response; male mating behavior; prepulse inhibition; adult locomotory behavior; positive regulation of apoptosis; regulation of dendrite morphogenesis; rhythmic process; regulation of synaptic plasticity; response to morphine; regulation of axonogenesis; sensory perception of pain; response to organic cyclic substance; calcium ion homeostasis; regulation of respiratory gaseous exchange; learning and/or memory; calcium ion transport; conditioned taste aversion; regulation of neuron apoptosis; visual learning; negative regulation of neuron apoptosis; cation transport; protein tetramerization; associative learning; synaptic transmission, glutamatergic; neuromuscular process; response to amphetamine; social behavior; learning; respiratory gaseous exchange; pons maturation; memory; cellular calcium ion homeostasis; regulation of membrane potential; response to ethanol; suckling behavior; regulation of synaptogenesis; long-term memory; olfactory learning; propylene metabolic process; ionotropic glutamate receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; response to calcium ion; regulation of excitatory postsynaptic membrane potential; regulation of neuronal synaptic plasticity; response to amine stimulus
Research Articles on Grin1
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Product Notes
The Grin1 grin1 (Catalog #AAA802964) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The GluN1-NR1 Antibody: ATTO 488 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GluN1-NR1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC). 1ug/mL (WB), 0.1-1ug/mL (IHC). Researchers should empirically determine the suitability of the Grin1 grin1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GluN1-NR1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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