Western Blot (WB)
(Western blot analysis of 1) Hela, 2) 293T, 3) Mouse Brain Tissue, 4) Rat Brain Tissue using GAP-43 Monoclonal Antibody.)
Mouse GAP-43 Monoclonal Antibody | anti-GAP-43 antibody
GAP-43 Monoclonal Antibody
Immunohistochemistry: 1:200-500
Western Blot (WB)
(Western blot analysis of 1) Hela, 2) 293T, 3) Mouse Brain Tissue, 4) Rat Brain Tissue using GAP-43 Monoclonal Antibody.)
Western Blot (WB)
(Western blot analysis of 1) Hela, 2) 293T, 3) Mouse Brain Tissue, 4) Rat Brain Tissue using GAP-43 Monoclonal Antibody.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using GAP-43 Monoclonal Antibody.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using GAP-43 Monoclonal Antibody.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
GAP43: This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Belongs to the neuromodulin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface
Chromosomal Location of Human Ortholog: 3q13.31
Cellular Component: filopodium membrane; axon; cytoplasm; postsynaptic density; plasma membrane; cell junction
Molecular Function: calmodulin binding; protein binding
Biological Process: cell fate commitment; glial cell differentiation; tissue regeneration; regulation of growth; axon choice point recognition; protein kinase C activation; response to wounding; regulation of filopodium formation
Research Articles on GAP-43
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Product Notes
The GAP-43 gap43 (Catalog #AAA9400181) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The GAP-43 Monoclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GAP-43 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:1000-2000 Immunohistochemistry: 1:200-500. Researchers should empirically determine the suitability of the GAP-43 gap43 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GAP-43, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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