Mouse anti-Mouse, Rat GABA Receptor A, delta Monoclonal Antibody | anti-GABRG3 antibody

GABA Receptor A, delta (Gamma-aminobutyric Acid Receptor Type A delta Subunit, GABRAd)

Cat. Num. AAA632370

• Reactivity: Mouse, Rat
• Applications: Western Blot, Immunocytochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: GABA Receptor A; delta; Monoclonal Antibody; delta (Gamma-aminobutyric Acid Receptor Type A delta Subunit; GABRAd); Anti -GABA Receptor A; anti-GABRG3 antibody

• Host: Mouse
• Reactivity: Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 10F704
• Specificity: Recognizes rat GABA-A-R-Delta.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH7.4, 50% glycerol and 0.09% sodium azide.

• Applicable Applications for anti-GABRG3 antibody: Western Blot (WB), Immunocytochemistry (ICC)
• Application Notes: Dilution: Western Blot:1-10ug/ml; Immunocytochemistry: 0.1-1ug/ml
• Immunogen: Synthetic peptide aa 15-34 of rat GABA-A-R-Delta (also known as gamma-aminobutyric acid receptor subunit delta, accession number P18506).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-GABRG3 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand-gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic

Product Categories/Family for anti-GABRG3 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 110347416
• NCBI GeneID: 2567
• NCBI Accession #: NP_150092.2
• NCBI GenBank Nucleotide #: NM_033223.4
• UniProt Accession #: Q99928; Q9HD46; Q9NYT2; G3V594
• Molecular Weight: 54,289 Da
• NCBI Official Full Name: gamma-aminobutyric acid receptor subunit gamma-3 isoform 1
• NCBI Official Synonym Full Names: gamma-aminobutyric acid (GABA) A receptor, gamma 3
• NCBI Official Symbol: GABRG3
• NCBI Protein Information: gamma-aminobutyric acid receptor subunit gamma-3; GABA(G) receptor, gamma 3; GABA(A) receptor subunit gamma-3
• UniProt Protein Name: Gamma-aminobutyric acid receptor subunit gamma-3
• Protein Family: Gamma-aminobutyric acid receptor
• UniProt Gene Name: GABRG3
• UniProt Entry Name: GBRG3_HUMAN

NCBI Description

This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

Uniprot Description

GABRG3: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG3 sub-subfamily.

Protein type: Transporter; Membrane protein, multi-pass; Transporter, ion channel; Channel, ligand-gated; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q12

Cellular Component: postsynaptic membrane; plasma membrane; cell junction

Molecular Function: chloride channel activity; GABA-A receptor activity; extracellular ligand-gated ion channel activity

Biological Process: response to drug; synaptic transmission; transmembrane transport; gamma-aminobutyric acid signaling pathway