Mouse GA Binding Protein Transcription Factor, alpha Monoclonal Antibody | anti-GABPA antibody

GA Binding Protein Transcription Factor, alpha (GABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A)

Cat. Num. AAA632261

• Gene Names: GABPA; NFT2; NRF2; NRF2A; E4TF1A; E4TF1-60
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: GA Binding Protein Transcription Factor; alpha; Monoclonal Antibody; alpha (GABPA; E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A); Anti -GA Binding Protein Transcription Factor; anti-GABPA antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 8C154
• Specificity: Recognizes human GA Binding Protein Transcription Factor, alpha.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

• Applicable Applications for anti-GABPA antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blotting.; Dilution: Western Blotting: 1:1000-1:2000
• Immunogen: Partial sequence of recombinant full-length protein to human GA Binding Protein Transcription Factor, alpha
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

Product Categories/Family for anti-GABPA antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 62897889
• NCBI GeneID: 2551
• UniProt Accession #: Q06546; Q12939; Q8IYS3
• Molecular Weight: 51,295 Da
• NCBI Official Full Name: GA binding protein transcription factor, alpha subunit (60kD) variant
• NCBI Official Synonym Full Names: GA binding protein transcription factor, alpha subunit 60kDa
• NCBI Official Symbol: GABPA
• NCBI Official Synonym Symbols: NFT2; NRF2; NRF2A; E4TF1A; E4TF1-60
• NCBI Protein Information: GA-binding protein alpha chain; GABP subunit alpha; OTTHUMP00000096113; OTTHUMP00000096114; transcription factor E4TF1-60; nuclear respiratory factor 2 alpha subunit; nuclear respiratory factor 2 subunit alpha; human nuclear respiratory factor-2 subunit alpha
• UniProt Protein Name: GA-binding protein alpha chain
• Protein Family: GA-binding protein
• UniProt Gene Name: GABPA
• UniProt Synonym Gene Names: E4TF1A
• UniProt Entry Name: GABPA_HUMAN

NCBI Description

This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

Uniprot Description

GABPA: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene. Belongs to the ETS family.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 21q21.3

Cellular Component: nucleoplasm; nuclear chromatin; nucleus

Molecular Function: protein binding; DNA binding; protein heterodimerization activity; transcription coactivator activity; chromatin binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; mitochondrion organization and biogenesis; in utero embryonic development; organelle organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; cell differentiation; negative regulation of megakaryocyte differentiation