Testing Data
(Fig.1: FACS analysis of BOSC23 cells using GM- 1D6 Cat.# GM0601. BOSC23 cells were transiently transfected with an expression vector encoding either FPRL1 (red curve) or an irrelevant protein (control transfectant: black curve). Binding of GM- 1D6 was detected with a PE-conjugated secondary antibody. A positive signal was obtained only with FPRL1 transfected cells.)
Mouse anti-Human FPRL1 Monoclonal Antibody | anti-FPR2 antibody
anti-human formyl peptide-receptor-like-1 (FPRL1) monoclonal antibody
Flow Cytometry: 1.2 ug/10^6 cells
CELISA: 1:200 - 1:400
Testing Data
(Fig.1: FACS analysis of BOSC23 cells using GM- 1D6 Cat.# GM0601. BOSC23 cells were transiently transfected with an expression vector encoding either FPRL1 (red curve) or an irrelevant protein (control transfectant: black curve). Binding of GM- 1D6 was detected with a PE-conjugated secondary antibody. A positive signal was obtained only with FPRL1 transfected cells.)
Testing Data
(Fig.1: FACS analysis of BOSC23 cells using GM- 1D6 Cat.# GM0601. BOSC23 cells were transiently transfected with an expression vector encoding either FPRL1 (red curve) or an irrelevant protein (control transfectant: black curve). Binding of GM- 1D6 was detected with a PE-conjugated secondary antibody. A positive signal was obtained only with FPRL1 transfected cells.)
Testing Data #2
(Fig.2: Spectral Confocal Microscopy of CHO cells using GM1-D6 Cat.# GM-0601. CHO cells were transiently transfected with an expression vector encoding FPRL1. Binding of GM-1D6 was visualized with a FITC-conjugated secondary antibody (green). Actin filaments are labeled with Alexa Fluor-555 Phalloidin (red). Cell nuclei are stained with DAPI (blue).)
Testing Data #2
(Fig.2: Spectral Confocal Microscopy of CHO cells using GM1-D6 Cat.# GM-0601. CHO cells were transiently transfected with an expression vector encoding FPRL1. Binding of GM-1D6 was visualized with a FITC-conjugated secondary antibody (green). Actin filaments are labeled with Alexa Fluor-555 Phalloidin (red). Cell nuclei are stained with DAPI (blue).)
Testing Data #3
(SDS-PAGE analysis of GM-1D6 The antibody was purified by protein G affinity chromatography from cell culture supernatants and verified by SDS-Page (Fig.3). Fig.3: SDS-PAGE analysis of purified GM-1D6 monoclonal antibody. Lane 1: molecular weight marker, Lane 2: 2 ?g of purified GM-1D6 antibody. Proteins were separated by SDSPAGE and stained with RAPID StainTM Reagent.)
Testing Data #3
(SDS-PAGE analysis of GM-1D6 The antibody was purified by protein G affinity chromatography from cell culture supernatants and verified by SDS-Page (Fig.3). Fig.3: SDS-PAGE analysis of purified GM-1D6 monoclonal antibody. Lane 1: molecular weight marker, Lane 2: 2 ?g of purified GM-1D6 antibody. Proteins were separated by SDSPAGE and stained with RAPID StainTM Reagent.)
Cui Y, Le Y, Yazawa H, Gong W, Wang JM (2002). Potential role of the formyl peptide receptorlike 1 (FPRL1) in inflammatory aspects of Alzheimer's disease. J Leukoc Biol 72(4):628-35
Elagoz A, Henderson D, Babu PS, Salter S, Grahames C, Bowers L, Roy MO, Laplante P, Grazzini E, Ahmad S and PM Lembo (2004). A truncated form of CKbeta8-1 is a potent agonist for human formyl peptide-receptor-like 1 receptor. Br J Pharmacol 141: 37-46.
NCBI and Uniprot Product Information
Uniprot Description
FPR2: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1
Chromosomal Location of Human Ortholog: 19q13.3-q13.4
Cellular Component: plasma membrane; integral to membrane
Molecular Function: G-protein coupled receptor activity; N-formyl peptide receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; cell adhesion; chemotaxis; inflammatory response; cell motility
Research Articles on FPR2
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Product Notes
The FPR2 fpr2 (Catalog #AAA468016) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The anti-human formyl peptide-receptor-like-1 (FPRL1) monoclonal antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FPRL1 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Immunofluorescence: 1 ug/10^6 cells Flow Cytometry: 1.2 ug/10^6 cells CELISA: 1:200 - 1:400. Researchers should empirically determine the suitability of the FPR2 fpr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FPRL1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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