Mouse FOOT-AND-MOUTH DISEASE VIRUS NON-STRUCTURAL PROTEIN 3a Monoclonal Antibody | anti-Lpro antibody

MOUSE ANTI FOOT-AND-MOUTH DISEASE VIRUS NON-STRUCTURAL PROTEIN 3a

Cat. Num. AAA216325

• Applications: ELISA
• Synonyms: FOOT-AND-MOUTH DISEASE VIRUS NON-STRUCTURAL PROTEIN 3a; Monoclonal Antibody; MOUSE ANTI FOOT-AND-MOUTH DISEASE VIRUS NON-STRUCTURAL PROTEIN 3a; anti-Lpro antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 1G2
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 1.0 mg/ml (varies by lot)
• Sequence Length: 2,308

• Applicable Applications for anti-Lpro antibody: ELISA (EIA)
• Perservative Stabilisers: 0.09% Sodium Azide; Preparation
• Immunogen: Recombinant FMDV non structural protein 3a.; Buffer Solution
• Target Species: Viral
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Related Product Information for anti-Lpro antibody

Mouse anti Foot-and-Mouth Disease Virus Non-Structural Protein 3a antibody, clone 1G2 recognizes the 3a non-structural protein of Foot-and-mouth disease virus (FMDV). Foot-and-mouth disease virus is a nonenveloped icosahedral Aphthovirus that contains single-stranded RNA. Foot-and-mouth disease is a highly contagious and sometimes fatal disease of cattle, pigs and other cloven-hoofed animals. The disease is characterised by high fever and blisters inside the mouth and on the feet. Although it doesn't have a high mortality rate, the disease has debilitating effects, including weight loss and decrease in milk production, resulting in detrimental economic ramifications. The virus is spread through direct contact. The non-structural proteins are necessary for viral replication and as such mutations in this area are probably less well tolerated than in the rest of the genome. Non-structural proteins have been targeted as possible targets to distinguish between infected and vaccinated animals.

NCBI and Uniprot Product Information

• NCBI GI #: 1346741
• UniProt Accession #: P49303; Q65094
• Molecular Weight: 256,785 Da
• NCBI Official Full Name: Genome polyprotein
• UniProt Protein Name: Genome polyprotein
• UniProt Gene Name: Lpro
• UniProt Synonym Gene Names: P2A; P2B; P2C; P3A; P3B-1; P3B-2; P3B-3; P3C; P3D-POL
• UniProt Entry Name: POLG_FMDVZ

Uniprot Description

The leader protease autocatalytically cleaves itself from the polyprotein at the L/VP0 junction. It cleaves the host translation initiation factors EIF4G1 and EIF4G3, in order to shut down the capped cellular mRNA transcription. Increases translation driven by the viral internal ribosome entry site (IRES).