Mouse Follicular Dendritic Cells Monoclonal Antibody | anti-FDCSP antibody
Mouse monoclonal Follicular Dendritic Cells antibody
Gene Names
FDCSP; C4orf7; FDC-SP
Applications
Western Blot, Immunohistochemistry
Purity
Method of Purification: Follicular Dendritic Cells antibody was purified by affinity chromatography.
Synonyms
Follicular Dendritic Cells; Monoclonal Antibody; Mouse monoclonal Follicular Dendritic Cells antibody; Follicular Dendritic Cells antibody; anti-FDCSP antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgM
Clone Number
CNA.42
Specificity
Human
Purity/Purification
Method of Purification: Follicular Dendritic Cells antibody was purified by affinity chromatography.
Form/Format
Affinity purified antibody supplied as a liquid in PBS , pH 7.2, with 0.09% NaN3
Concentration
0.5 mg/mL (varies by lot)
Sequence Length
85
Applicable Applications for anti-FDCSP antibody
Flow , Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Assay Information: The bioactivity of this protein was determined by transmigration assay of human monocytes. Maximum chemotaxis is observed at less than or equal to 100 ng/ml.
Biological Significance: The monoclonal antibody CNA.42 recognizes a unique carbohydrate epitope found on follicular dendritic cells from a variety of species. FDCs are large cells in germinal centers of primary and lymphoid tissues. They present non-processed antigen and switch off apoptosis of B cells through a selection process resulting in selection of memory B cells. FDCs express many B cell markers such as CD21, CD23 and CD35. A role for FDCs as been shown in various infectious diseases such as AIDS and transmissible spongiform encephalitis. Staining with this CNA.42 monoclonal antibody is mainly restricted to the plasma membrane but in limited cases may also be cytoplasmic. This monoclonal has been shown to be a useful reagent for both flow cytometry and IHC analysis.
Biological Significance: The monoclonal antibody CNA.42 recognizes a unique carbohydrate epitope found on follicular dendritic cells from a variety of species. FDCs are large cells in germinal centers of primary and lymphoid tissues. They present non-processed antigen and switch off apoptosis of B cells through a selection process resulting in selection of memory B cells. FDCs express many B cell markers such as CD21, CD23 and CD35. A role for FDCs as been shown in various infectious diseases such as AIDS and transmissible spongiform encephalitis. Staining with this CNA.42 monoclonal antibody is mainly restricted to the plasma membrane but in limited cases may also be cytoplasmic. This monoclonal has been shown to be a useful reagent for both flow cytometry and IHC analysis.
Cross-Reactivity
Human
Preparation and Storage
Store at 4°C.
Product Categories/Family for anti-FDCSP antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
follicular dendritic cell secreted peptide
NCBI Official Synonym Full Names
follicular dendritic cell secreted protein
NCBI Official Symbol
FDCSP
NCBI Official Synonym Symbols
C4orf7; FDC-SP
NCBI Protein Information
follicular dendritic cell secreted peptide
UniProt Protein Name
Follicular dendritic cell secreted peptide
Protein Family
UniProt Gene Name
FDCSP
UniProt Synonym Gene Names
C4orf7; FDC secreted protein; FDC-SP
NCBI Description
This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. [provided by RefSeq, Dec 2011]
Uniprot Description
FDCSP: Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q13.3|4q13
Research Articles on FDCSP
Similar Products
Product Notes
The FDCSP fdcsp (Catalog #AAA5306108) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Follicular Dendritic Cells can be used in a range of immunoassay formats including, but not limited to, Flow, Western Blot (WB), Immunohistochemistry (IHC). Assay Information: The bioactivity of this protein was determined by transmigration assay of human monocytes. Maximum chemotaxis is observed at less than or equal to 100 ng/ml. Biological Significance: The monoclonal antibody CNA.42 recognizes an unique carbohydrate epitope found on follicular dendritic cells from a variety of species. FDCs are large cells in germinal centers of primary and lymphoid tissues. They present non-processed antigen and switch off apoptosis of B cells through a selection process resulting in selection of memory B cells. FDCs express many B cell markers such as CD21, CD23 and CD35. A role for FDCs as been shown in various infectious diseases such as AIDS and transmissible spongiform encephalitis. Staining with this CNA.42 monoclonal antibody is mainly restricted to the plasma membrane but in limited cases may also be cytoplasmic. This monoclonal has been shown to be an useful reagent for both flow cytometry and IHC analysis. Researchers should empirically determine the suitability of the FDCSP fdcsp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Follicular Dendritic Cells, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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