Mouse FK506 Binding Protein 4 Monoclonal Antibody | anti-FKBP4 antibody

Mouse Anti Human FK506 Binding Protein 4

Cat. Num. AAA140251

• Gene Names: Fkbp4; p59; FKBP-4; FKBP-52
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: FKBP4 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Synonyms: FK506 Binding Protein 4; Monoclonal Antibody; Mouse Anti Human FK506 Binding Protein 4; FKBP4 Antibody; Mouse Anti Human; HBI; p52; Hsp56; FKBP52; FKBP59; PPIase; FKBP4; FK506-binding protein 4; Peptidyl-prolyl cis-trans isomerase; HSP-binding immunophilin; FKBP52 protein; 52 kDa FK506-binding protein; p59 protein; anti-FKBP4 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b heavy chain and kappa light chain
• Clone Number: PAT4D3AT
• Purity/Purification: FKBP4 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Form/Format: 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
• Sequence Length: 458

• Applicable Applications for anti-FKBP4 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: FKBP4 antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot is 1:1,000 ~ 1:2,000 and immunohistochemistry analysis is 1:50~100. Recommended starting dilution for Western blot is 1:1,000 and Immunohistochemistry is 1:50.
• Immunogen: Anti-human FKBP4 mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human FKBP4 amino acids 1-459 purified from E Coli.
• Preparation and Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.; 12 months at -20 degree C. 1 month at 4 degree C.

Related Product Information for anti-FKBP4 antibody

Introduction: FKBP4 is part of the immunophilin protein family, which takes part in immunoregulation and necessary cellular processes concerning protein folding and trafficking. FKBP4 is a cis-trans prolyl isomerase that connects to the immunosuppressants FK506 and rapamycin. FKBP4 has high structural and functional similarity to FKBP1A, though, FKBP4 does not have immunosuppressant activity when complexed with FK506. FKBP4 interacts with interferon regulatory factor-4 and is involved in immunoregulatory gene expression in B and T lymphocytes. FKBP4 is known to connect with phytanoyl-CoA alpha-hydroxylase. FKBP4 associates with HSP90 & HSP70 thus takes part in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. FKBP4 highly associates with adeno-associated virus type 2 vectors (AAV) resulting in a considerable increase in AAV-mediated transgene expression in human cell lines. FKBP4 is involved in the optimal use of AAV vectors in human gene therapy.

Product Categories/Family for anti-FKBP4 antibody

Monoclonal Antibodies; Anti-Human Enzymes; Monoclonal Antibodies; Anti Human Enzyme

NCBI and Uniprot Product Information

• NCBI GI #: 149049321
• NCBI GeneID: 260321
• Molecular Weight: 51,450 Da
• NCBI Official Full Name: FK506 binding protein 4
• NCBI Official Synonym Full Names: FK506 binding protein 4
• NCBI Official Symbol: Fkbp4
• NCBI Official Synonym Symbols: p59; FKBP-4; FKBP-52
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase FKBP4; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 52; FK506-binding protein 4; FKBP52 protein; FKBP59; HBI; HSP-binding immunophilin; PPIase FKBP4; immunophilin FKBP52; rotamase
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP4
• Protein Family: Peptidyl-prolyl cis-trans isomerase
• UniProt Gene Name: Fkbp4
• UniProt Synonym Gene Names: Fkbp52; PPIase FKBP4; 52 kDa FKBP; FKBP-52; p59; FKBP-4; HBI
• UniProt Entry Name: FKBP4_RAT

Uniprot Description

FKBP4: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.

Protein type: Chaperone; Isomerase; EC 5.2.1.8

Cellular Component: nucleoplasm; microtubule; endoplasmic reticulum membrane; neuron projection; protein complex; cell soma; mitochondrion; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus

Molecular Function: FK506 binding; peptidyl-prolyl cis-trans isomerase activity; GTP binding; heat shock protein binding; phosphoprotein binding; tau protein binding; copper-dependent protein binding; ATP binding; glucocorticoid receptor binding

Biological Process: prostate gland development; male sex differentiation; steroid hormone receptor complex assembly; protein complex localization; protein peptidyl-prolyl isomerization; negative regulation of microtubule polymerization; androgen receptor signaling pathway; negative regulation of microtubule polymerization or depolymerization; copper ion transport; reproductive structure development; embryo implantation