Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human liver tissue using at dilution of 1:200.)
Mouse anti-Human Ferritin light chain Monoclonal Antibody | anti-FTL antibody
Ferritin light chain Monoclonal Antibody
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human liver tissue using at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human liver tissue using at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human brain tissue using at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human brain tissue using at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human lymph node tissue using at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human lymph node tissue using at dilution of 1:200.)
NCBI and Uniprot Product Information
Uniprot Description
FTL: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS). It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene. Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3); also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels. Belongs to the ferritin family.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: cytoplasm; cytosol; ferritin complex; membrane
Molecular Function: identical protein binding; iron ion binding; protein binding
Biological Process: cellular iron ion homeostasis; intracellular sequestering of iron ion; iron ion homeostasis
Disease: Hyperferritinemia With Or Without Cataract; L-ferritin Deficiency; Neurodegeneration With Brain Iron Accumulation 3
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Product Notes
The FTL ftl (Catalog #AAA9415044) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Ferritin light chain Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Ferritin light chain can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:20 - 1:200. Researchers should empirically determine the suitability of the FTL ftl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ferritin light chain, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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