Mouse anti-Human FceRI, alpha Monoclonal Antibody | anti-FCER1A antibody

FceRI, alpha (Fc epsilon RI alpha, FCE1A, FCER1A, High Affinity Immunoglobulin epsilon Receptor Subunit alpha, IgE Receptor) (MaxLight 550)

Cat. Num. AAA6254910

• Gene Names: FCER1A; FCE1A; FcERI
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay, Immunofluorescence, Immunoprecipitation, Western Blot
• Purity: Purified by protein G affinity chromatography from tissue culture supernatant.
• Synonyms: FceRI; alpha; Monoclonal Antibody; alpha (Fc epsilon RI alpha; FCE1A; FCER1A; High Affinity Immunoglobulin epsilon Receptor Subunit alpha; IgE Receptor) (MaxLight 550); Fc Fragment of IgE; High Affinity I; Receptor for alpha polypeptide; IgE Fc Receptor Subunit alpha; Fc-epsilon RI-alpha; anti-FCER1A antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 10C204
• Specificity: Recognizes the extracellular D1 domain of human FceRI, alpha.
• Purity/Purification: Purified by protein G affinity chromatography from tissue culture supernatant.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight550.

• Applicable Applications for anti-FCER1A antibody: Flow Cytometry (FC/FACS), FLISA, Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB)
• Conjugate: MaxLight550
• Preparation and Storage: Store at 4 degree C. Do Not Freeze.

Testing Data

(Staining of human peripheral blood cells with F0025-06b2, showing staining of eosinophils)

Product Categories/Family for anti-FCER1A antibody

Antibodies; Receptors

References

1. Vangelista, L. et al. (2002) A minimal receptor-Ig chimera of human Fc epsilon R1 alpha-chain efficiently binds secretory and membrane IgE. Protein Engineering. 15: 51-57, 2. Vangelista, L. et al. (2002) Efficient folding of the Fc epsilonR1 alpha-chain membrane-proximal domain D2 depends on the presence of the N-terminal domain D1. J. Mol. Biol. 322: 815-25

NCBI and Uniprot Product Information

• NCBI GI #: 119865
• NCBI GeneID: 2205
• UniProt Accession #: P12319
• Molecular Weight: 30kDa
• NCBI Official Full Name: High affinity immunoglobulin epsilon receptor subunit alpha
• NCBI Official Synonym Full Names: Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
• NCBI Official Symbol: FCER1A
• NCBI Official Synonym Symbols: FCE1A; FcERI
• NCBI Protein Information: high affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; Fc epsilon RI alpha-chain; igE Fc receptor subunit alpha; Fc IgE receptor, alpha polypeptide; high affinity immunoglobulin epsilon receptor alpha-subunit; immunoglobulin E r
• UniProt Protein Name: High affinity immunoglobulin epsilon receptor subunit alpha
• Protein Family: High affinity immunoglobulin epsilon receptor
• UniProt Gene Name: FCER1A
• UniProt Synonym Gene Names: FCE1A; FcERI
• UniProt Entry Name: FCERA_HUMAN

NCBI Description

The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]

Uniprot Description

Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.