Western Blot (WB)
(Western Blot detection against Immunogen (37.84kD).)
Mouse anti-Human EVC Monoclonal Antibody | anti-EVC antibody
EVC (Ellis-van Creveld Syndrome Protein, DWF-1)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: Sandwich ELISA: The detection limit is 0.3ng/ml as a capture antibody
Western Blot (WB)
(Western Blot detection against Immunogen (37.84kD).)
Western Blot (WB)
(Western Blot detection against Immunogen (37.84kD).)
Testing Data
(Detection limit for recombinant GST tagged EVC is 0.3ng/ml as a capture antibody.)
Testing Data
(Detection limit for recombinant GST tagged EVC is 0.3ng/ml as a capture antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein containing a leucine zipper and a transmembrane domain. This gene has been implicated in both Ellis-van Creveld syndrome (EvC) and Weyers acrodental dysostosis. [provided by RefSeq, Jul 2008]
Uniprot Description
EVC: Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development. Defects in EVC are a cause of Ellis-van Creveld syndrome (EVC); also known as chondroectodermal dysplasia. EVC is an autosomal recessive disorder characterized by the clinical tetrad of chondrodystrophy, polydactyly, ectodermal dysplasia and cardiac anomalies. Patients manifest short-limb dwarfism, short ribs, postaxial polydactyly and dysplastic nails and teeth. Congenital heart defects, most commonly an atrioventricular septal defect, are observed in 60% of affected individuals. Defects in EVC are a cause of acrofacial dysostosis Weyers type (WAD); also known as Curry-Hall syndrome. Acrofacial dysostoses are a heterogeneous group of disorders combining limb defects with facial abnormalities. WAD is an autosomal dominant disorder characterized by dysplastic nails, postaxial polydactyly, acrofacial dysostosis, short limbs and short stature. The phenotype is milder than Ellis-van Creveld syndrome.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p16
Cellular Component: cytoplasm; integral to membrane; cilium
Biological Process: smoothened signaling pathway; muscle development; cartilage development; positive regulation of smoothened signaling pathway; skeletal development
Disease: Weyers Acrofacial Dysostosis; Ellis-van Creveld Syndrome
Research Articles on EVC
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Product Notes
The EVC evc (Catalog #AAA6011593) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The EVC (Ellis-van Creveld Syndrome Protein, DWF-1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's EVC can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: Sandwich ELISA: The detection limit is 0.3ng/ml as a capture antibody. Researchers should empirically determine the suitability of the EVC evc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: VLERQRLMQC DLEEEENVRA TEAVVALCQE LYFSTVDTFQ KFVDALFLQT LPGMTGLPPE ECDYLRQEVQ ENAAWQLGKS NRFRRQQWKL FQELLEQDQQ VWMEECALSS. It is sometimes possible for the material contained within the vial of "EVC, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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