Immunohistochemistry (IHC)
(Formalin-fixed, paraffin-embedded breast cancer stained with Estrogen receptor beta ERb455 antibody at 1:200 using peroxidase-conjugate and DAB chromogen.)
Mouse Estrogen Receptor, beta Monoclonal Antibody | anti-ES antibody
Estrogen Receptor, beta (ES) (APC)
IP: 1-2ug/500ug protein lysate
WB: 0.5-1ug/ml
Applications are based on unconjugated antibody.
Immunohistochemistry (IHC)
(Formalin-fixed, paraffin-embedded breast cancer stained with Estrogen receptor beta ERb455 antibody at 1:200 using peroxidase-conjugate and DAB chromogen.)
Immunohistochemistry (IHC)
(Formalin-fixed, paraffin-embedded breast cancer stained with Estrogen receptor beta ERb455 antibody at 1:200 using peroxidase-conjugate and DAB chromogen.)
Immunohistochemistry (IHC)
(Formalin-fixed, paraffin-embedded ovarian cancer stained with Estrogen receptor beta ERb455 antibody at 1:200 using peroxidase-conjugate and DAB chromogen.)
Immunohistochemistry (IHC)
(Formalin-fixed, paraffin-embedded ovarian cancer stained with Estrogen receptor beta ERb455 antibody at 1:200 using peroxidase-conjugate and DAB chromogen.)
NCBI and Uniprot Product Information
Uniprot Description
ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 14q23.2
Cellular Component: nucleoplasm; mitochondrion; extracellular region; nucleus
Molecular Function: ligand-dependent nuclear receptor activity; receptor antagonist activity; protein binding; estrogen receptor activity; enzyme binding; DNA binding; zinc ion binding; transcription coactivator activity; estrogen response element binding; steroid hormone receptor activity; transcription factor activity; steroid binding
Biological Process: transcription initiation from RNA polymerase II promoter; estrogen receptor signaling pathway; induction of apoptosis by hormones; neuron migration; vagina development; negative regulation of transcription from RNA polymerase II promoter; uterus development; signal transduction; cell-cell signaling; ovarian follicle development; regulation of transcription, DNA-dependent; steroid hormone mediated signaling; positive regulation of transcription factor activity; gene expression; brain development; negative regulation of cell growth; negative regulation of epithelial cell proliferation
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Product Notes
The ES esr2 (Catalog #AAA6122250) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Estrogen Receptor, beta (ES) (APC) reacts with Equine, Human, Monkey, Mouse, Porcine, Rat, Sheep and may cross-react with other species as described in the data sheet. AAA Biotech's Estrogen Receptor, beta can be used in a range of immunoassay formats including, but not limited to, FLISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB). IF: 1-2ug/ml IP: 1-2ug/500ug protein lysate WB: 0.5-1ug/ml Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the ES esr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Estrogen Receptor, beta, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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