Western Blot (WB)
(Western Blot detection against Immunogen (36.63kD).)
Mouse anti-Human ERN1 Monoclonal Antibody | anti-ERN1 antibody
ERN1 (Serine/Threonine-protein Kinase/Endoribonuclease IRE1, Endoplasmic Reticulum-to-nucleus Signaling 1, Inositol-requiring Protein 1, hIRE1p, Ire1-alpha, IRE1a, IRE1) (AP)
Western Blot (WB)
(Western Blot detection against Immunogen (36.63kD).)
Western Blot (WB)
(Western Blot detection against Immunogen (36.63kD).)
Western Blot (WB)
(ERN1 monoclonal antibody, Western Blot analysis of ERN1 expression in HeLa.)
Western Blot (WB)
(ERN1 monoclonal antibody, Western Blot analysis of ERN1 expression in HeLa.)
Immunofluorescence (IF)
(Immunofluorescence of monoclonal antibody to ERN1 on HeLa cell. [antibody concentration 25ug/ml].)
Immunofluorescence (IF)
(Immunofluorescence of monoclonal antibody to ERN1 on HeLa cell. [antibody concentration 25ug/ml].)
Testing Data
(Detection limit for recombinant GST tagged ERN1 is ~0.03ng/ml as a capture antibody.)
Testing Data
(Detection limit for recombinant GST tagged ERN1 is ~0.03ng/ml as a capture antibody.)
Testing Data
(Proximity Ligation Analysis (PLA) of protein-protein interactions between TRAF2 and ERN1. HeLa cells were stained with TRAF2 rabbit purified polyclonal 1:1200 and ERN1 mouse monoclonal antibody 1:50. Signals were detected by 30 Detection Kit 613 (red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.)
Testing Data
(Proximity Ligation Analysis (PLA) of protein-protein interactions between TRAF2 and ERN1. HeLa cells were stained with TRAF2 rabbit purified polyclonal 1:1200 and ERN1 mouse monoclonal antibody 1:50. Signals were detected by 30 Detection Kit 613 (red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]
Research Articles on ERN1
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Product Notes
The ERN1 (Catalog #AAA6131168) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ERN1 (Serine/Threonine-protein Kinase/Endoribonuclease IRE1, Endoplasmic Reticulum-to-nucleus Signaling 1, Inositol-requiring Protein 1, hIRE1p, Ire1-alpha, IRE1a, IRE1) (AP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ERN1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the ERN1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ERN1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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