Rabbit anti-Human ErbB3/HER3  Monoclonal Antibody | anti-ErbB3/HER3  antibody

Rabbit anti Human ErbB3/HER3  Monoclonal Antibody

Cat. Num. AAA2543878

• Gene Names: Erbb3; nuc-ErbB3
• Reactivity: Human
• Applications: ELISA
• Synonyms: ErbB3/HER3 ; Monoclonal Antibody; Rabbit anti Human ErbB3/HER3 Monoclonal Antibody; anti-ErbB3/HER3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 1339

• Applicable Applications for anti-ErbB3/HER3 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human ErbB3.
• Immunogen: Recombinant Human HER3/ErbB3 Protein
• Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Human HER3/ErbB3 (rh HER3/ErbB3; Met 1-Thr 643; NP_001973.2).
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-ErbB3/HER3  antibody

ErbB3, also known as Her3 (human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

NCBI and Uniprot Product Information

• NCBI GI #: 17352449
• NCBI GeneID: 29496
• Molecular Weight: 147,546 Da
• NCBI Official Full Name: ErbB3/Her3
• NCBI Official Synonym Full Names: erb-b2 receptor tyrosine kinase 3
• NCBI Official Symbol: Erbb3
• NCBI Official Synonym Symbols: nuc-ErbB3
• NCBI Protein Information: receptor tyrosine-protein kinase erbB-3
• UniProt Protein Name: Receptor tyrosine-protein kinase erbB-3
• UniProt Gene Name: Erbb3
• UniProt Entry Name: ERBB3_RAT

NCBI Description

acts as a tyrosine kinase receptor for neuregulin; may play a role in axonal regeneration in response to injury [RGD, Feb 2006]

Uniprot Description

HER3: a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described.

Protein type: EC 2.7.10.1; EGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Cellular Component: apical plasma membrane; basolateral plasma membrane; extracellular space; integral to membrane; lateral plasma membrane; nucleus; postsynaptic membrane; receptor complex

Molecular Function: growth factor binding; identical protein binding; protein heterodimerization activity; protein tyrosine kinase activator activity; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: axonogenesis; cellular response to insulin stimulus; circadian rhythm; cranial nerve development; epidermal growth factor receptor signaling pathway; mammary gland involution; negative regulation of cell adhesion; negative regulation of neuron apoptosis; negative regulation of secretion; negative regulation of signal transduction; neuron apoptosis; odontogenesis; peripheral nervous system development; phosphoinositide 3-kinase cascade; positive regulation of cardiac muscle development; positive regulation of glucose import; regulation of cell proliferation; response to drug; response to wounding; Schwann cell differentiation; signal transduction; skeletal muscle development; tongue development; transmembrane receptor protein tyrosine kinase signaling pathway