Western Blot (WB)
(Western blot analysis using EphB3 mouse mAb against truncated EphB3-His recombinant protein.)
Mouse anti-Human EphB3 Monoclonal Antibody | anti-EphB3 antibody
Anti-EphB3 Mouse mAb
Western Blot (WB)
(Western blot analysis using EphB3 mouse mAb against truncated EphB3-His recombinant protein.)
Western Blot (WB)
(Western blot analysis using EphB3 mouse mAb against truncated EphB3-His recombinant protein.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human lung squamous cell carcinoma (A), lung adenocarcinoma (B), colon carcinoma (C), breast carcinoma (D), normal sublingual gland (E), normal rectal (F), showing membrane localization with DAB staining u)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human lung squamous cell carcinoma (A), lung adenocarcinoma (B), colon carcinoma (C), breast carcinoma (D), normal sublingual gland (E), normal rectal (F), showing membrane localization with DAB staining u)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human Adrenal tissues using EPHB3 mouse mAb)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human Adrenal tissues using EPHB3 mouse mAb)
NCBI and Uniprot Product Information
NCBI Description
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]
Uniprot Description
EphB3: a ubiquitous receptor tyrosine kinase of the Eph family. A receptor for ephrin-B family members: ephrin-B1 and -B2. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels.EphB3 contains 1 sterile alpha motif (SAM) domain and 2 fibronectin type III domains.
Protein type: EC 2.7.10.1; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 3q27.1
Cellular Component: cytosol; extracellular region; integral to plasma membrane; plasma membrane
Molecular Function: ephrin receptor activity
Biological Process: angiogenesis; axon guidance; axonal fasciculation; cell migration; corpus callosum development; digestive tract morphogenesis; ephrin receptor signaling pathway; palate development; positive regulation of synaptogenesis; protein amino acid autophosphorylation; regulation of axonogenesis; regulation of cell-cell adhesion; regulation of GTPase activity; thymus development; urogenital system development
Research Articles on EphB3
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Product Notes
The EphB3 ephb3 (Catalog #AAA475799) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-EphB3 Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's EphB3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the EphB3 ephb3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EphB3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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