Mouse anti-Human EPC1 Monoclonal Antibody | anti-EPC1 antibody

EPC1 (Enhancer of Polycomb Homolog 1, DKFZp781P2312, Epl1)

Cat. Num. AAA6005312

• Gene Names: EPC1; Epl1
• Reactivity: Human
• Applications: ELISA
• Purity: Ascites; Ascites
• Synonyms: EPC1; Monoclonal Antibody; EPC1 (Enhancer of Polycomb Homolog 1; DKFZp781P2312; Epl1); Anti -EPC1 (Enhancer of Polycomb Homolog 1; anti-EPC1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgM,k
• Clone Number: 4F7
• Specificity: Recognizes human EPC1.
• Purity/Purification: Ascites; Ascites
• Form/Format: Supplied as a liquid in ascites fluid.
• Sequence: KGLHLSSTTPTALVHTSPSTAGSALLQPSNITQTSSSHSALSHQVTAANSATTQVLIGNNIRLTVPSSVATVNSIAPINARHIPRTLSAVPSSALKLAAAANCQ

• Applicable Applications for anti-EPC1 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.
• Immunogen: Partial recombinant corresponding to aa695-799 from human EPC1 (NP_079485) with GST tag. MW of the GST tag alone is 26kD.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-EPC1 antibody

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.

Product Categories/Family for anti-EPC1 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 538260600
• NCBI GeneID: 80314
• NCBI Accession #: NP_001269320.1
• NCBI GenBank Nucleotide #: NM_001282391.1
• UniProt Accession #: Q9H2F5; Q5VW54; Q5VW56; Q5VW58; Q8NAQ4; Q8NE21; Q96LF4; Q96RR6; Q9H7T7; B4DSC3; D3DRX7
• Molecular Weight: 93,463 Da
• NCBI Official Full Name: enhancer of polycomb homolog 1 isoform d
• NCBI Official Synonym Full Names: enhancer of polycomb homolog 1 (Drosophila)
• NCBI Official Symbol: EPC1
• NCBI Official Synonym Symbols: Epl1
• NCBI Protein Information: enhancer of polycomb homolog 1
• UniProt Protein Name: Enhancer of polycomb homolog 1
• Protein Family: Enhancer of polycomb
• UniProt Gene Name: EPC1
• UniProt Entry Name: EPC1_HUMAN

NCBI Description

This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Uniprot Description

EPC1: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Belongs to the enhancer of polycomb family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Acetyltransferase; Nuclear envelope

Chromosomal Location of Human Ortholog: 10p11

Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; nuclear membrane; nucleus

Molecular Function: histone acetyltransferase activity

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; negative regulation of gene expression, epigenetic; regulation of growth; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent