Mouse anti-Human Eotaxin-3 Monoclonal Antibody | anti-CCL26 antibody
Mouse Anti-Human Eotaxin-3
Gene Names
CCL26; IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha
Reactivity
Human
Synonyms
Eotaxin-3; Monoclonal Antibody; Mouse Anti-Human Eotaxin-3; Monoclonal antibody anti-human Eotaxin-3; anti-CCL26 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1, kappa
Form/Format
Lyophilized
Sequence Length
94
Application Notes
ELISA: This antibody can be used at a concentration of 1-2 ug/ml, as a capture antibody in conjunction with a compatible secondary reagent to yield satisfactory results in a sandwich ELISA.
Antibody Generation
Monoclonal antibodies were produced in BALB/c mice using recombinant hEotaxin-3 as the immunizing antigen. IgG1/K antibody was purified from ascites fluid on a Protein A affinity column.
Neutralization
To yield one-half maximal inhibition [ND50] of the biological activity of hEotaxin-3 (2 ug/ml), a concentration of 1-5 ug/ml of this antibody is required.
Related Product Information for anti-CCL26 antibody
Eotaxin3, also named CCL26 or SCYA26, is a novel human CC chemokine that maps to chromosome 7q11.2, within 40 kilobases of the Eotaxin2 loci. Eotaxin3/ CCL26 has been shown to be constitutively expressed in the heart and ovary. In addition, low levels of Eotaxin3/ CCL26 expression can also be detected in various tissues. The expression of Eotaxin 3/CCL26 in vascular endothelial cells has been shown to be upregulated by IL13 and IL4. Eotaxin3/ CCL26 cDNA encodes a 94 amino acid (aa) residue protein with a putative signal peptide of either 23 or 26 aa residues. Eotaxin3/ CCL26 induces calcium flux in eosinophils as well as in CCR3transfected cells. Eotaxin 3/ CCL26 has also been shown to cross-desensitize cells to other CCR3 ligands.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
10,648 Da
NCBI Official Full Name
C-C motif chemokine 26
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 26
NCBI Official Symbol
CCL26
NCBI Official Synonym Symbols
IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha
NCBI Protein Information
C-C motif chemokine 26; eotaxin-3; MIP-4-alpha; chemokine N1; CC chemokine IMAC; thymic stroma chemokine-1; small inducible cytokine A26; small-inducible cytokine A26; macrophage inflammatory protein 4-alpha; small inducible cytokine subfamily A (Cys-Cys), member 26
UniProt Protein Name
C-C motif chemokine 26
Protein Family
UniProt Gene Name
CCL26
UniProt Synonym Gene Names
SCYA26; MIP-4-alpha; TSC-1
UniProt Entry Name
CCL26_HUMAN
NCBI Description
This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Chemotactic for eosinophils and basophils. Binds to CCR3.
Subunit structure: Monomer.
Subcellular location: Secreted.
Tissue specificity: Ubiquitously expressed at low levels in various tissues including heart and ovary.
Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.
Research Articles on CCL26
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Product Notes
The CCL26 ccl26 (Catalog #AAA690820) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human Eotaxin-3 reacts with Human and may cross-react with other species as described in the data sheet. ELISA: This antibody can be used at a concentration of 1-2 ug/ml, as a capture antibody in conjunction with a compatible secondary reagent to yield satisfactory results in a sandwich ELISA. Researchers should empirically determine the suitability of the CCL26 ccl26 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Eotaxin-3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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