Mouse anti-Human Elongator Protein 1 Monoclonal Antibody | anti-IKBKAP antibody

Elongator Protein 1 (ELP1, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-cells, Kinase Complex-associated Protein, IKBKAP, DYS, ELP1, FD, FLJ12497, IKAP, IKI3, P150, TOT1, DKFZP781H1425)

Cat. Num. AAA608856

• Gene Names: IKBKAP; FD; DYS; ELP1; IKAP; IKI3; TOT1; FLJ12497; DKFZp781H1425
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Elongator Protein 1; Monoclonal Antibody; Elongator Protein 1 (ELP1; Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-cells; Kinase Complex-associated Protein; IKBKAP; DYS; ELP1; FD; FLJ12497; IKAP; IKI3; P150; TOT1; DKFZP781H1425); Anti -Elongator Protein 1 (ELP1; anti-IKBKAP antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 9F621
• Specificity: Recognizes human ELP1
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.

• Applicable Applications for anti-IKBKAP antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA: 1:1000
• Immunogen: Elongator complex (130kD)
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-IKBKAP antibody

Its function is not clear, but it has been demonstrated that the human Elongator facilitates transcription by RNA polymerase II in a chromatin- and acetyl-CoA-dependent manner. IKBKAP. IKBKAP was originally described as a scaffold protein of the IKK complex involved in NF-kB activation, but this role has since been disputed. IKBKAP is a component of the RNA polymerase II elongator complex which has histone acetyltransferase activity and is involved in transcriptional elongation. Gene defects are a cause of familial dysautonomia, also known as Riley-Day syndrome. Affected individuals show a variety of symptoms such as decreased sensitivity to pain and temperature, cardiovascular instability, pneumonia and gastrointestinal dysfunction.

Product Categories/Family for anti-IKBKAP antibody

Antibodies; Abs to Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 38569394
• NCBI GeneID: 8518
• NCBI Accession #: NP_003631.2
• NCBI GenBank Nucleotide #: NM_003640.3
• UniProt Accession #: O95163; Q5JSV2; Q9H327; Q9UG87; Q4LE38; Q68DI5; Q8N516
• Molecular Weight: 150,254 Da
• NCBI Official Full Name: elongator complex protein 1
• NCBI Official Synonym Full Names: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
• NCBI Official Symbol: IKBKAP
• NCBI Official Synonym Symbols: FD; DYS; ELP1; IKAP; IKI3; TOT1; FLJ12497; DKFZp781H1425
• NCBI Protein Information: elongator complex protein 1; p150; OTTHUMP00000021869; IKK complex-associated protein; ikappaB kinase complex-associated protein
• UniProt Protein Name: Elongator complex protein 1
• UniProt Gene Name: IKBKAP
• UniProt Synonym Gene Names: ELP1; IKAP
• UniProt Entry Name: ELP1_HUMAN

NCBI Description

The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. [provided by RefSeq]

Uniprot Description

IKBKAP: May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3. Belongs to the ELP1/IKA1 family.

Protein type: Protein kinase, regulatory subunit; Transcription regulation

Chromosomal Location of Human Ortholog: 9q31

Cellular Component: transcription elongation factor complex; Elongator holoenzyme complex; cytoplasm; nucleolus; histone acetyltransferase complex

Molecular Function: signal transducer activity; protein binding; phosphorylase kinase regulator activity

Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; RNA elongation from RNA polymerase II promoter; immune response; protein complex assembly; signal transduction; regulation of protein kinase activity; protein amino acid phosphorylation; positive regulation of cell migration

Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Iii