Mouse anti-Human Ectodysplasin A Receptor Monoclonal Antibody | anti-EDAR antibody

Mouse Anti Human Ectodysplasin A Receptor

Cat. Num. AAA140512

• Gene Names: EDAR; DL; ED3; ED5; ED1R; EDA3; HRM1; EDA1R; ECTD10A; ECTD10B; EDA-A1R
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified from mouse ascitic fluids by protein-A affinity chromatography
• Synonyms: Ectodysplasin A Receptor; Monoclonal Antibody; Mouse Anti Human Ectodysplasin A Receptor; EDAR Antibody; Mouse Anti Human; DL; Ectodysplasin 1; Anhidrotic Receptor; Anhidrotic Ectodysplasin Receptor 1; Ectodermal Dysplasia Receptor; Ectodysplasin-A Receptor; Downless Homolog; EDA-A1 Receptor; ECTD10A; ECTD10B; EDA3; HRM1; ED3; Tumor Necrosis Factor Receptor Superfamily Member EDAR; Downless; Mouse; Homolog Of; EDA-A1R; EDA1R; ED1R; ED5; Tumor necrosis factor receptor superfamily member EDAR; anti-EDAR antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Clone Number: PAT19E8AT
• Purity/Purification: Purified from mouse ascitic fluids by protein-A affinity chromatography
• Form/Format: 1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.; Sterile filtered colorless solution.
• Sequence Length: 448

• Applicable Applications for anti-EDAR antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: EDAR antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity.
• Ig Subclass: Mouse IgG2a heavy chain and k light chain.
• Immunogen: Anti-human EDAR mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human EDAR protein 27-448 amino acids purified from E Coli.
• Preparation and Storage: Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.; Stability: 12 months at -20 degree C. 1 month at 4 degree C.

Related Product Information for anti-EDAR antibody

Ectodysplasin A Receptor, also known as EDAR belongs to the tumor necrosis factor receptor family. EDAR is a receptor for the soluble ligand ectodysplasin A, and is capable of activating the nuclear factor-kappaB, JNK, as well as caspase-independent cell death pathways. EDAR is necessary for the development of hair, teeth, and other ectodermal derivatives. Furthermore, mutations in EDAR resulted in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.

Product Categories/Family for anti-EDAR antibody

Monoclonal/Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 62739796
• NCBI GeneID: 10913
• Molecular Weight: 51,690 Da
• NCBI Official Full Name: Ectodysplasin A receptor
• NCBI Official Synonym Full Names: ectodysplasin A receptor
• NCBI Official Symbol: EDAR
• NCBI Official Synonym Symbols: DL; ED3; ED5; ED1R; EDA3; HRM1; EDA1R; ECTD10A; ECTD10B; EDA-A1R
• NCBI Protein Information: tumor necrosis factor receptor superfamily member EDAR
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member EDAR
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: EDAR
• UniProt Synonym Gene Names: DL
• UniProt Entry Name: EDAR_HUMAN

Uniprot Description

EDAR: Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA); also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. Defects in EDAR are the cause of ectodermal dysplasia type 3 (ED3); also known as ectodermal dysplasia hypohidrotic autosomal dominant or EDA3. ED3 is an autosomal dominant condition characterized by hypotrichosis, abnormal or missing teeth, and hypohidrosis due to the absence of sweat glands.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 2q13

Cellular Component: plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: epidermis development; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; tumor necrosis factor-mediated signaling pathway

Disease: Ectodermal Dysplasia 10a, Hypohidrotic/hair/nail Type, Autosomal Dominant; Ectodermal Dysplasia 10b, Hypohidrotic/hair/tooth Type, Autosomal Recessive; Hair Morphology 1