Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of EAAT3 protein using Mouse Anti-EAAT3 Monoclonal Antibody, Clone S180-41. Primary Antibody: Mouse Anti-EAAT3 Monoclonal Antibody at 1:1000.)
Mouse anti-Human EAAC1 Monoclonal Antibody | anti-SLC1A1 antibody
EAAC1 Antibody: Alkaline Phosphatase
Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of EAAT3 protein using Mouse Anti-EAAT3 Monoclonal Antibody, Clone S180-41. Primary Antibody: Mouse Anti-EAAT3 Monoclonal Antibody at 1:1000.)
Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of EAAT3 protein using Mouse Anti-EAAT3 Monoclonal Antibody, Clone S180-41. Primary Antibody: Mouse Anti-EAAT3 Monoclonal Antibody at 1:1000.)
Scientific Background: SLC1A1/EAAT3/EAAC1, a member of this transporter family, is expressed throughout the body, particularly in brain, intestine, liver, heart and kidney. Functional defects of the SLC1A1 gene are found in patients of dicarboxylicamino aciduria.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]
Uniprot Description
SLC1A1: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A1 subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 9p24
Cellular Component: membrane; integral to plasma membrane; apical plasma membrane; plasma membrane
Molecular Function: glutamate binding; cysteine transmembrane transporter activity; sodium:dicarboxylate symporter activity; glutamate:sodium symporter activity; L-glutamate transmembrane transporter activity
Biological Process: synaptic transmission; L-glutamate import; cysteine transport; ion transport; transmembrane transport; protein homooligomerization
Disease: Schizophrenia 18
Research Articles on SLC1A1
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Product Notes
The SLC1A1 slc1a1 (Catalog #AAA800775) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The EAAC1 Antibody: Alkaline Phosphatase reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's EAAC1 can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP). 1:1000 (WB). Researchers should empirically determine the suitability of the SLC1A1 slc1a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EAAC1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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