Rabbit anti-Human APOBEC3C Polyclonal Antibody | anti-APOBEC3C antibody

APOBEC3C Polyclonal Antibody

Cat. Num. AAA3011462

• Gene Names: APOBEC3C; A3C; PBI; ARP5; ARDC2; ARDC4; APOBEC1L; bK150C2.3
• Reactivity: Human
• Applications: Western Blot, Immunoprecipitation
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: APOBEC3C; Polyclonal Antibody; APOBEC3C Polyclonal Antibody; DNA dC->dU-editing enzyme APOBEC-3C; A3C; APOBEC1-like; Phorbolin I; APOBEC1L; PBI; anti-APOBEC3C antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: APOBEC3C polyclonal antibody detects endogenous levels of APOBEC3C protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 190

• Applicable Applications for anti-APOBEC3C antibody: Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: WB: 1:500-1:2000; IP: 1:50-1:100
• Immunogen: Recombinant full length Human APOBEC3C.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Testing Data

Related Product Information for anti-APOBEC3C antibody

APOBEC (apolipoprotein B mRNA editing enzyme, catalytic) proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention.

NCBI and Uniprot Product Information

• NCBI GI #: 22907039
• NCBI GeneID: 27350
• NCBI Accession #: NP_055323
• NCBI GenBank Nucleotide #: NP_055323.2
• UniProt Accession #: Q9NRW3
• NCBI Official Full Name: DNA dC->dU-editing enzyme APOBEC-3C
• NCBI Official Synonym Full Names: apolipoprotein B mRNA editing enzyme catalytic subunit 3C
• NCBI Official Symbol: APOBEC3C
• NCBI Official Synonym Symbols: A3C; PBI; ARP5; ARDC2; ARDC4; APOBEC1L; bK150C2.3
• NCBI Protein Information: DNA dC->dU-editing enzyme APOBEC-3C
• UniProt Protein Name: DNA dC->dU-editing enzyme APOBEC-3C
• Protein Family: DNA dC->dU-editing enzyme
• UniProt Gene Name: APOBEC3C
• UniProt Synonym Gene Names: APOBEC1L; PBI; A3C
• UniProt Entry Name: ABC3C_HUMAN

NCBI Description

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]