Immunocytochemistry (ICC)
(Immunocytochemistry Analysis: Representative lot data. Confocal fluorescent analysis of Ntera-2 cells using FITC-conjugated DRD4 (Green). Nucleus is stained with ethidium bromide (Red). This antibody positively stains the cell membrane. (Wolstencroft, E.C., et al. (2007). J Mol Histol. 38(4):333-340.))
Mouse DRD4 Monoclonal Antibody | anti-DRD4 antibody
DRD4 (D(4) Dopamine Receptor, D(2C) Dopamine Receptor, Dopamine D4 Receptor) (AP)
Immunocytochemistry (ICC)
(Immunocytochemistry Analysis: Representative lot data. Confocal fluorescent analysis of Ntera-2 cells using FITC-conjugated DRD4 (Green). Nucleus is stained with ethidium bromide (Red). This antibody positively stains the cell membrane. (Wolstencroft, E.C., et al. (2007). J Mol Histol. 38(4):333-340.))
Immunocytochemistry (ICC)
(Immunocytochemistry Analysis: Representative lot data. Confocal fluorescent analysis of Ntera-2 cells using FITC-conjugated DRD4 (Green). Nucleus is stained with ethidium bromide (Red). This antibody positively stains the cell membrane. (Wolstencroft, E.C., et al. (2007). J Mol Histol. 38(4):333-340.))
Western Blot (WB)
(Western Blotting Analysis: Representative lot data. Mouse brain tissue lysate was probed with DRD4 (0.5ug/ml). Proteins were visualized using a Goat Mouse IgG secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates DRD4 (~48kD).)
Western Blot (WB)
(Western Blotting Analysis: Representative lot data. Mouse brain tissue lysate was probed with DRD4 (0.5ug/ml). Proteins were visualized using a Goat Mouse IgG secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates DRD4 (~48kD).)
Western Blot (WB)
(Western Blotting Analysis: Representative lot data. Rat brain tissue lysate was probed with DRD4 (0.5ug/ml). Proteins were visualized using a Goat Rat IgG secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates DRD4 (~48kD).)
Western Blot (WB)
(Western Blotting Analysis: Representative lot data. Rat brain tissue lysate was probed with DRD4 (0.5ug/ml). Proteins were visualized using a Goat Rat IgG secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates DRD4 (~48kD).)
NCBI and Uniprot Product Information
Uniprot Description
DRD4: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: membrane; cell soma; integral to plasma membrane; plasma membrane; dendritic spine; terminal button; vesicle membrane; cell cortex
Molecular Function: dopamine D2 receptor-like receptor activity; identical protein binding; protein binding; potassium channel regulator activity; dopamine receptor activity; dopamine binding; drug binding; SH3 domain binding
Biological Process: circadian rhythm; synaptic transmission, dopaminergic; fear response; behavioral fear response; positive regulation of dopamine uptake; adult locomotory behavior; short-term memory; activation of MAPK activity; regulation of neurotransmitter secretion; positive regulation of kinase activity; regulation of calcium-mediated signaling; behavioral response to ethanol; dopamine metabolic process; dopamine receptor, adenylate cyclase inhibiting pathway; regulation of inhibitory postsynaptic membrane potential; negative regulation of cAMP biosynthetic process; behavioral response to cocaine; negative regulation of protein secretion; negative regulation of adenylate cyclase activity; regulation of dopamine metabolic process; response to amphetamine; social behavior; regulation of circadian rhythm; arachidonic acid secretion; cellular calcium ion homeostasis; olfactory learning; response to steroid hormone stimulus; retina development in camera-type eye; photoperiodism; dopamine receptor signaling pathway; positive regulation of sodium:hydrogen antiporter activity
Disease: Novelty Seeking Personality Trait; Attention Deficit-hyperactivity Disorder
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Product Notes
The DRD4 drd4 (Catalog #AAA6241986) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The DRD4 (D(4) Dopamine Receptor, D(2C) Dopamine Receptor, Dopamine D4 Receptor) (AP) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DRD4 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Western Blot (WB). Researchers should empirically determine the suitability of the DRD4 drd4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DRD4, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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