Mouse anti-Human Diazepam Binding Inhibitor Monoclonal Antibody | anti-DBI antibody

Diazepam Binding Inhibitor (DBI, Acyl-CoA-binding Protein, ACBP, Endozepine, EP)

Cat. Num. AAA609259

• Gene Names: DBI; EP; ACBP; ACBD1; CCK-RP; MGC70414
• Reactivity: Human
• Applications: ELISA, Immunoprecipitation
• Purity: Ascites; Ascites
• Synonyms: Diazepam Binding Inhibitor; Monoclonal Antibody; Diazepam Binding Inhibitor (DBI; Acyl-CoA-binding Protein; ACBP; Endozepine; EP); Anti -Diazepam Binding Inhibitor (DBI; anti-DBI antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1, k
• Clone Number: 10K185
• Specificity: Recognizes human Diazepam Binding Inhibitor.
• Purity/Purification: Ascites; Ascites
• Form/Format: Supplied as a liquid in PBS, 50% glycerol.

• Applicable Applications for anti-DBI antibody: ELISA (EL/EIA), Immunoprecipitation (IP)
• Application Notes: Suitable for use in ELISA and Immunoprecipitation.; Dilution: Immunoprecipitation: 1-2ul/400ul lysates
• Immunogen: Recombinant human GST fusion protein purified from E.coli.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-DBI antibody

Diazepam Binding Inhibitor (DBI) is a highly conserved 10kD polypeptide which is expressed in various species range from yeast to mammals. As an inverse agonist for benzodiazepine receptors, DBI downregulates inhibitory effects of GABA. It also has potential to induce anxiety. Found in central andperipheral tissues, DBI also participates in metabolism of steroids, which has been known to partially modify GABAA receptor function in the CNS. In peripheral tissues, DBI plays regulatory roles in steroidogenesis. DBI levels have been reported to be decreased in the cerebrospinal fluid obtained from patients with Alzheimer disease.

Product Categories/Family for anti-DBI antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 181478
• NCBI GeneID: 1622
• UniProt Accession #: P07108; P08869; Q4VWZ6; Q53SQ7; Q6IB48; Q9UCI8
• Molecular Weight: 10,044 Da
• NCBI Official Full Name: diazepam binding inhibitor
• NCBI Official Synonym Full Names: diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
• NCBI Official Symbol: DBI
• NCBI Official Synonym Symbols: EP; ACBP; ACBD1; CCK-RP; MGC70414
• NCBI Protein Information: acyl-CoA-binding protein; endozepine; OTTHUMP00000203626; OTTHUMP00000203627; OTTHUMP00000203628; OTTHUMP00000203629; GABA receptor modulator; diazepam-binding inhibitor; acyl coenzyme A binding protein; acyl-Coenzyme A binding domain containing 1; cholecystokinin-releasing peptide, trypsin-sensitive; diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)
• UniProt Protein Name: Acyl-CoA-binding protein
• Protein Family: Acyl-CoA-binding protein
• UniProt Gene Name: DBI
• UniProt Entry Name: ACBP_HUMAN

NCBI Description

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]

Uniprot Description

DBI: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. Belongs to the ACBP family. 6 isoforms of the human protein are produced by alternative promoter.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 2q12-q21

Cellular Component: Golgi apparatus; mitochondrion; endoplasmic reticulum

Molecular Function: protein dimerization activity; benzodiazepine receptor binding; lipid binding

Biological Process: behavioral fear response; protein palmitoylation; triacylglycerol metabolic process; learning and/or memory; hair follicle development; transport; lateral ventricle development