Rat anti-Mouse Dectin-1 Monoclonal Antibody | anti-DECTIN1 antibody

Dectin-1 (C-type Lectin Domain Family 7 Member A, Dendritic Cell-associated C-type Lectin 1, DC-associated C-type Lectin 1, Beta-glucan Receptor, beta-GR, C-type Lectin Superfamily Member 12, CLEC7A, BGR, CLECSF12, DECTIN1, UNQ539/PRO1082) (MaxLight 490)

Cat. Num. AAA6253818

• Gene Names: Clec7a; BGR; beta-GR; Clecsf12
• Reactivity: Mouse
• Applications: Flow Cytometry, Functional Assay, Immunohistochemistry, Immunoprecipitation
• Purity: Purified by Protein G Affinity Chromatography
• Synonyms: Dectin-1; Monoclonal Antibody; Dectin-1 (C-type Lectin Domain Family 7 Member A; Dendritic Cell-associated C-type Lectin 1; DC-associated C-type Lectin 1; Beta-glucan Receptor; beta-GR; C-type Lectin Superfamily Member 12; CLEC7A; BGR; CLECSF12; DECTIN1; UNQ539/PRO1082) (MaxLight 490); anti-DECTIN1 antibody

• Host: Rat
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 10B2689
• Specificity: Recognizes mouse Dectin-1. Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells.
• Purity/Purification: Purified by Protein G Affinity Chromatography
• Form/Format: Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight490.

• Applicable Applications for anti-DECTIN1 antibody: Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1. UniProt Accession #: Q6QLQ4
• Conjugate: MaxLight490
• Preparation and Storage: Store at 4 degree C. Do Not Freeze.

Testing Data

(Staining of mouse peritoneal macrophages with RAT ANTI MOUSE BETA-GLUCAN RECEPTOR: FITC)

Product Categories/Family for anti-DECTIN1 antibody

Antibodies; Lectins

References

1. Brown, G. D. et al. (2002) Dectin-1 is a major beta-glucan receptor on macrophages. J. Exp. Med. 196:407-412.2. Taylor, P. R. et al. (2002) The beta-glucan receptor, Dectin-1 is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. J. Immunol. 169:3876-3882.3. Reid, D.M. et al. (2004) Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions. J. Leuk. Biol. 76:86-94.4. Underhill, D.M. et al. (2005) Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood 106:2543-2550.

NCBI and Uniprot Product Information

• NCBI GI #: 188035930
• NCBI GeneID: 56644
• NCBI Accession #: NP_064392
• NCBI GenBank Nucleotide #: NM_020008.3
• UniProt Accession #: Q6QLQ4; Q8K1L4; Q9JI50; E9QPW2
• Molecular Weight: 21.0kDa (183aa) 18-28KDa (SDS-PAGE under reducing conditions.)
• NCBI Official Full Name: C-type lectin domain family 7 member A 1
• NCBI Official Synonym Full Names: C-type lectin domain family 7, member a
• NCBI Official Symbol: Clec7a
• NCBI Official Synonym Symbols: BGR; beta-GR; Clecsf12
• NCBI Protein Information: C-type lectin domain family 7 member A
• UniProt Protein Name: C-type lectin domain family 7 member A
• UniProt Gene Name: Clec7a
• UniProt Synonym Gene Names: Bgr; Clecsf12; Dectin1; DC-associated C-type lectin 1; Dectin-1

Uniprot Description

Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.